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Journal of Neurology

, Volume 248, Issue 2, pp 121–126 | Cite as

Uric acid levels in sera from patients with multiple sclerosis

  • Jelena Drulović
  • Irena Dujmović
  • Nebojša Stojsavljević
  • Šarlota Mesaroš
  • Slobodanka Andjelković
  • Djordje Miljković
  • Vesna Perić
  • Gradimir Dragutinović
  • Jelena Marinković
  • Zvonimir Lević
  • Marija Mostarica Stojković
Original communication

Abstract

The levels of uric acid (UA), a natural peroxynitrite scavenger, were measured in sera from 240 patients with multiple sclerosis (MS) and 104 sex- and age-matched control patients with other neurological diseases (OND). The mean serum UA concentration was lower in the MS than in the OND group, but the difference did not reach the level of statistical significance (P=0.068). However, the mean serum UA level from patients with active MS (202.6+67.1 μmol/l) was significantly lower than that in inactive MS patients (226.5+78.6 μmol/l; P=0.046) and OND controls (P=0.007). We found a significant inverse correlation of serum UA concentration with female gender (P=0.0001), disease activity (P=0.012) and duration (P=0.017), and a trend towards an inverse correlation with disability as assessed by EDSS score, which did not reach statistical significance (P=0.067). Finally, multivariate linear regression analyses showed that UA concentration was independently correlated with gender (P=0.0001), disease activity (P=0.014) and duration of the disease (P=0.043) in MS patients. These findings suggest that serum UA might serve as a possible marker of disease activity in MS. They also provide support to the potential beneficial therapeutic effect of radical-scavenging substances in MS.

Key words Multiple sclerosis Uric acid Peroxynitrite Disease activity Magnetic resonance imaging 

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Copyright information

© Steinkopff Verlag 2001

Authors and Affiliations

  • Jelena Drulović
    • 1
  • Irena Dujmović
    • 1
  • Nebojša Stojsavljević
    • 1
  • Šarlota Mesaroš
    • 1
  • Slobodanka Andjelković
    • 2
  • Djordje Miljković
    • 3
  • Vesna Perić
    • 4
  • Gradimir Dragutinović
    • 4
  • Jelena Marinković
    • 5
  • Zvonimir Lević
    • 1
  • Marija Mostarica Stojković
    • 6
  1. 1.Institute of Neurology, Clinical Centre of Serbia, School of Medicine, University of Belgrade, Dr Subotića 6, Belgrade 11000, Yugoslavia, Tel.: + 3 81-11-68 43 55, Fax: +3 81-11-68 45 77, e-mail: chcondru@EUnet.yuYU
  2. 2.Institute of Medical Biochemistry, Clinical Centre of Serbia, Višegradska 26, Belgrade 11000, YugoslaviaYU
  3. 3.Institute for Biological Research, 29 Novembra 142, Belgrade 11000, YugoslaviaYU
  4. 4.MRI Centre, Clinical Centre of Serbia, Pasterova 2, Belgrade 11000, YugoslaviaYU
  5. 5.Institute of Biostatistics, Public Health and Research in Medicine, School of Medicine, University of Belgrade, Dr Subotića 15, Belgrade 11000, YugoslaviaYU
  6. 6.Institute for Microbiology and Immunology, School of Medicine, University of Belgrade, Dr Subotića 1, Belgrade 11000, YugoslaviaYU

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