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Journal of Neurology

, Volume 247, Issue 5, pp 376–382 | Cite as

Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation

  • G. Comi
  • L. Kappos
  • M. Clanet
  • G. Ebers
  • A. Fassas
  • F. Fazekas
  • M. Filippi
  • H.P. Hartung
  • B. Hertenstein
  • D. Karussis
  • G. Martino
  • A. Tyndall
  • F.G.A. van der Meché
  • and the BMT-MS Study Group
Original communication

Abstract

Recent reports suggest the possible beneficial effects of haemopoietic stem cell transplantation (HSCT) in autoimmune diseases such as multiple sclerosis (MS). The definition of the risk/benefit ratio for such a treatment is perceived as a major issue for the neurological community worldwide. The First Consensus Conference on Bone Marrow Transplantation in Patients with Multiple Sclerosis was held in Milan, Italy on 21 February 1998. Participants from 16 European, North American, and South American countries discussed the guidelines form performing HSCT in MS. This conference was organized in order to : (a) define criteria for patient selection; (b) define transplantation procedures to maximize efficacy of the treatment and minimize its toxicity; (c) standardize patient outcome evaluation; and (d) establish an international working group to evaluate the efficacy and safety of HSCT in MS and to study the immunological changes related to HSCT in MS patients. During the meeting in Milan agreement was reached on: (a) the preparation and distribution of a consensus report on HSCT in MS and (b) the design of an open trial for an initial assessment of the safety and efficacy of HSCT in MS. The consensus reached during the meeting and the design of the clinical trial are summarized in this contribution.

Key words Multiple sclerosis Haemopoietic stem cell transplantation Consensus guidelines 

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Copyright information

© Steinkopff Verlag 2000

Authors and Affiliations

  • G. Comi
    • 1
  • L. Kappos
    • 2
  • M. Clanet
    • 3
  • G. Ebers
    • 4
  • A. Fassas
    • 5
  • F. Fazekas
    • 6
  • M. Filippi
    • 1
  • H.P. Hartung
    • 6
  • B. Hertenstein
    • 7
  • D. Karussis
    • 8
  • G. Martino
    • 1
  • A. Tyndall
    • 9
  • F.G.A. van der Meché
    • 10
  • and the BMT-MS Study Group
  1. 1.Multiple Sclerosis Centre, San Raffaele Scientific Institute, San Raffaele Hospital, Via Olgettina 48, 20 132 Milan, Italy, Tel.: +39-02-26432881, Fax: +39-02-26432881, E-mail: g.comi@hsr.itIT
  2. 2.Department of Neurology, Kantonsspital Basel, Basel, SwitzerlandCH
  3. 3.Service de Neurologie, Hôpital de Purpan, Toulouse, FranceFR
  4. 4.Department of Clinical Neurological Sciences, Division of Neurology, London Health Science Center, London-Ontario, CanadaCA
  5. 5.Department of Haematology, George Papanicolau General Hospital, Exkhi, GreeceGR
  6. 6.Department of Neurology, University of Graz, Graz, AustriaAT
  7. 7.Department of Haematology, Medizinische Hochschule Hannover, Hannover, GermanyDE
  8. 8.Department of Neurology, Hadassah University Hospital, Jerusalem, IsraelIL
  9. 9.Department of Rheumatology, Kantonsspital Basel, Basel SwitzerlandCH
  10. 10.Department of Neurology, University Hospital and Erasmus University, Rotterdam, The NetherlandsNL

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