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Journal of Neurology

, Volume 247, Issue 4, pp 286–290 | Cite as

Validity and reliability of two muscle strength scores commonly used as endpoints in assessing treatment of myasthenia gravis

  • T. Sharshar
  • S. Chevret
  • M. Mazighi
  • P. Chillet
  • G. Huberfeld
  • C. Berreotta
  • M. Houfani
  • P. Gajdos
Original communication

Abstract

Valid and reliable measurements of muscle impairment are needed to assess therapeutic efficacy in patients with generalized myasthenia gravis (MG). In 22 patients we compared the validity and interobserver reliability of two scoring methods commonly used as main endpoints in clinical trials, i.e., the Myasthenic Muscle Score (MMS) ranging from 0 to 100 (normal) and the Quantified Myasthenia Gravis Strength Score (QMGSS) ranging from 0 (normal) to 39. Each score is correlated more with functional scale and less with the patient’s self-evaluation. Using intraclass correlation ¶we found strong agreement between observers for both the MMS (r = 0.906) and the QMGSS (r = 0.905). The correlation between MMS and QGMSS was high (r = 0.87). The reliability of neither score depended on any specific item, since the removal of individual items did not significantly alter the intraclass correlation coefficient (ranging from 0.86 to 0.93).

Key words Myasthenia gravis Muscle strength Reliability 

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Copyright information

© Steinkopff Verlag 2000

Authors and Affiliations

  • T. Sharshar
    • 1
  • S. Chevret
    • 2
  • M. Mazighi
    • 1
  • P. Chillet
    • 1
  • G. Huberfeld
    • 1
  • C. Berreotta
    • 1
  • M. Houfani
    • 1
  • P. Gajdos
    • 1
  1. 1.Service de Réanimation Médicale, Hôpital Raymond Poincaré, 104 boulevard Raymond Poincaré, 92380 Garches, France Tel.: +33-1-47107778, Fax: +33-1-47107783FR
  2. 2.Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Paris, FranceFR

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