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Journal of Neurology

, Volume 246, Issue 10, pp 934–938 | Cite as

Primary central nervous system lymphoma presenting with a parkinsonian syndrome of pure akinesia

  • P. P. Pramstaller
  • A. Salerno
  • K. P. Bhatia
  • M. Prugger
  • C. D. Marsden
Original Communication

Abstract

The incidence of primary central nervous system lymphoma (PCNSL), once a rare tumour, has risen significantly in both immunocompetent and immunosuppressed patients. Although infiltration of the basal ganglia is not uncommon in PCNSL, extrapyramidal movement disorders are generally not recognised as a mode of clinical presentation of this type of cerebral tumour. We present the unusual case of a 75-year-old man who developed a parkinsonian syndrome of “pure akinesia” due to autopsy-confirmed PCNSL primarily involving the globus pallidus bilaterally. Parkinsonism due to bilateral pallidal lesions is known but rare, and such cases help in the understanding of basal ganglia function with regard to akinesia and freezing.

Key words Parkinsonism Akinesia Lymphoma 

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Copyright information

© Steinkopff Verlag 1999

Authors and Affiliations

  • P. P. Pramstaller
    • 1
  • A. Salerno
    • 2
  • K. P. Bhatia
    • 3
  • M. Prugger
    • 1
  • C. D. Marsden
    • 3
  1. 1.Department of Neurology, Regional General Hospital, Bolzano, ItalyIT
  2. 2.Department of Pathology, Regional General Hospital, Bolzano, ItalyIT
  3. 3.University Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1 N 3BG, UK Tel.: +44-171-8373611, Fax: +44-171-278-5616GB

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