Journal of Neurology

, Volume 246, Issue 5, pp 365–368

Medication-induced hallucination and cerebral blood flow in Parkinson’s disease

  • K. Okada
  • Nobuo Suyama
  • Hiroaki Oguro
  • Shuhei Yamaguchi
  • Shotai Kobayashi
Original communication

Abstract

Although hallucinations in Parkinson’s disease (PD) are not unusual in the long-term treatment with anti-parkinsonian agents, their mechanism is not fully understood. We compared both the neuropsychiatric state and the results of 99mTc-labeled hexamethyl propyleneamine oxime single-photon emission computed tomography in 12 PD patients with medication-induced hallucinations and 21 PD patients without hallucinations. Hallucinatory patients showed significantly lower cerebral blood flow in left temporal regions than nonhallucinatory patients. The cerebral blood flow reduction in these regions may be related to the mechanism of medication-induced hallucinations in PD.

Key words Hallucination Parkinson’s disease Cerebral blood flow Single photon emission computed tomography 

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Copyright information

© Steinkopff Verlag 1999

Authors and Affiliations

  • K. Okada
    • 1
  • Nobuo Suyama
    • 1
  • Hiroaki Oguro
    • 1
  • Shuhei Yamaguchi
    • 1
  • Shotai Kobayashi
    • 1
  1. 1.Department of Internal Medicine III, Shimane Medical University, 89-1 Enya-cho, Izumo 693, Japan, e-mail: okada@shimane-med.ac.jp, Tel.: +81-853-23–2111/2198 Fax: +81-853-20-2194JP

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