Journal of Neurology

, Volume 246, Issue 4, pp 304–308

Apolipoprotein E genotype and progression of Alzheimer’s disease: the Rotterdam Study

  • A. J. C. Slooter
  • Jeanine J. Houwing-Duistermaat
  • Frans van Harskamp
  • Marc Cruts
  • Christine Van Broeckhoven
  • Monique M. B. Breteler
  • Albert Hofman
  • T. Stijnen
  • Cornelia M. van Duijn
Original communication

DOI: 10.1007/s004150050351

Cite this article as:
Slooter, A., Houwing-Duistermaat, J., van Harskamp, F. et al. J Neurol (1999) 246: 304. doi:10.1007/s004150050351

Abstract

The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer’s disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patients were included at a similar stage, i.e., before the onset of symptoms, and followed for up to 5 years. We found that the APOE*4 allele is not a strong determinant of survival in AD. As change in cognitive function and severity of dementia are similar for AD patients with and without APOE*4, our study suggests that progression of AD is not related to the APOE*4 allele.

Key words Alzheimer’s disease Apolipoprotein E Progression Survival 

Copyright information

© Steinkopff Verlag 1999

Authors and Affiliations

  • A. J. C. Slooter
    • 1
  • Jeanine J. Houwing-Duistermaat
    • 1
  • Frans van Harskamp
    • 2
  • Marc Cruts
    • 3
  • Christine Van Broeckhoven
    • 3
  • Monique M. B. Breteler
    • 1
  • Albert Hofman
    • 1
  • T. Stijnen
    • 1
  • Cornelia M. van Duijn
    • 1
  1. 1.Department of Epidemiology and Biostatistics, Erasmus University Medical School, PO Box 1738, 3000 DR Rotterdam, The Netherlands e-mail: slooter@epib.fgg.eur.nl; Tel.: +31-10-4087485; Fax: +31-10-4366139NL
  2. 2.Department of Neurology, University Hospital Rotterdam, Erasmus University Medical School, Rotterdam, The NetherlandsNL
  3. 3.Neurogenetics Laboratory, Flanders Interuniversity Institute for Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Antwerpen, BelgiumBE

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