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Journal of Neurology

, Volume 245, Issue 12, pp 794–796 | Cite as

Reversible parkinsonism induced by prolonged treatment with valproate

  • M. Onofrj
  • Astrid Thomas
  • Cristina Paci
Original communiction

Abstract

We describe two patients who developed levodopa-responsive parkinsonism without dementia at least 4 years after beginning chronic valproate (VPA) treatment for seizures. Parkinsonism disappeared in less than 3 months after VPA substitution with carbamazepine.

Key words Parkinsonism Parkinson’s disease Epilepsy Valproate Levodopa 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • M. Onofrj
    • 1
  • Astrid Thomas
    • 1
  • Cristina Paci
    • 1
  1. 1.Dipartimento di Oncologia e Neuroscienze, Clinica Neurologica, via dei Vestini, I-66100 Chieti, Italy e-mail: onofrj@ibmpe.unich.it Tel.: +39-871-358527 Fax: +39-871-562019IT

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