Neurological complications of radiotherapy and chemotherapy
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- Keime-Guibert, F., Napolitano, M. & Delattre, JY. J Neurol (1998) 245: 695. doi:10.1007/s004150050271
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Neurological complications of radiotherapy and chemotherapy can affect the central or peripheral nervous system. Most are dose-dependent and constitute a limiting factor in the administration of treatments. Radiation-induced neurological complications are classified as acute, early-delayed or delayed. The most important are radionecrosis and cognitive dysfunction/leukoencephalopathy. Neurotoxicity of chemotherapy is frequent and depends upon dose, type of drugs (especially cisplatin and methotrexate) and their combination with radiotherapy.
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