Journal of Neurology

, Volume 245, Issue 11, pp 695–708

Neurological complications of radiotherapy and chemotherapy

  • Florence Keime-Guibert
  • Massimo Napolitano
  • J.-Y. Delattre
ENS review

DOI: 10.1007/s004150050271

Cite this article as:
Keime-Guibert, F., Napolitano, M. & Delattre, JY. J Neurol (1998) 245: 695. doi:10.1007/s004150050271

Abstract

Neurological complications of radiotherapy and chemotherapy can affect the central or peripheral nervous system. Most are dose-dependent and constitute a limiting factor in the administration of treatments. Radiation-induced neurological complications are classified as acute, early-delayed or delayed. The most important are radionecrosis and cognitive dysfunction/leukoencephalopathy. Neurotoxicity of chemotherapy is frequent and depends upon dose, type of drugs (especially cisplatin and methotrexate) and their combination with radiotherapy.

Key words Radiotherapy Chemotherapy Neurotoxicity 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Florence Keime-Guibert
    • 1
  • Massimo Napolitano
    • 1
  • J.-Y. Delattre
    • 1
  1. 1.Service de Neurologie, Hôpital de la Salpetrière, 47, boulevard de I’Hôpital, F-75 651 Paris Cedex 13, France Tel.: +33-1-42-16-03-85 Fax: +33-1-42-16-04-18FR

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