Journal of Neurology

, Volume 245, Issue 10, pp 659–664

Colour vision abnormalities do not correlate with dopaminergic nigrostriatal degeneration in Parkinson’s disease

  • T. Müller
  • Wilfried Kuhn
  • Thomas Büttner
  • Ernst Eising
  • H. Coenen
  • Martin Haas
  • Horst Przuntek
Original communication

Abstract

Sensory disturbances such as olfactory or visual dysfunctions are common in Parkinson’s disease (PD). A possible relationship between distorted colour discrimination and the nigrostriatal dopamine deficit is still a matter of debate. We examined 31 de novo Parkinsonian patients with [123I]β-CIT single photon emission tomography (SPECT). We used a single-head γ-camera and calculated the binding ratio striatum/cerebellum (specific/nonspecific binding) of [123I]β-CIT uptake. On the same day, we performed the Farnsworth-Munsell 100 Hue Test (FMT) in these patients and estimated the total error score, in order to investigate abnormalities of colour vision. Parkinsonian patients’ total error score was higher compared with an age- and sex-matched control group (P = < 0.0001), whereas disability scores of the Hoehn and Yahr scale (P = 0.019, Spearman r = 0.419) and the Unified Parkinson’s Disease Rating Scale (P = 0.039, Spearman r = 0.373) correlated with total error score. No significant association appeared between total error score (Spearman r = –0.119, P = 0.525) and [123I]β-CIT-SPECT ratio. Thus both total error scores of the FMT and [123I]β-CIT-SPECT binding ratios have been found to reflect the severity of PD. However, only [123I]β-CIT SPECT reflects degeneration of dopaminergic neurons of the basal ganglia, but does not reflect alterations of the visual system and/or extranigral lesions in PD. From our results, we speculate that FMT may be a valuable clinical method to measure extranigral lesions of the visual system in PD.

Key words Parkinson’s disease Colour discrimination [123I]β-CIT single photon emission tomography Nigrostriatal degeneration 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • T. Müller
    • 1
  • Wilfried Kuhn
    • 1
  • Thomas Büttner
    • 1
  • Ernst Eising
    • 2
  • H. Coenen
    • 2
  • Martin Haas
    • 1
  • Horst Przuntek
    • 1
  1. 1.Department of Neurology, St. Josef-Hospital, University of Bochum, Gudrunstr. 56, D-44791 Bochum, Germany, Tel.: +49-234-509-2426 Fax: +49-234-509-2426DE
  2. 2.Department of Nuclear Medicine, University GHS Essen, D-45122 Essen, GermanyDE

Personalised recommendations