Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis: a comparison with conventional T2-weighted images
- 182 Downloads
New magnetic resonance (MR) measures considered to be putative markers of demyelination and axonal loss were found to be more closely related to clinical disability than T2-weighted MR imaging (MRI) findings in patients with multiple sclerosis (MS). In this study, we evaluated the reproducibility of such measurements in order to assess their reliability for longitudinal studies in MS. The intra-observer coefficients of variation for repeated measurements did not significantly differ among the MR techniques studied [2.6% for T2-weighted MRI, 4.38% for unenhanced T1-weighted MRI, 3.65% for magnetisation transfer imaging (MTI) and 2.28% for spinal cord cross-sectional area at C5]. Our findings suggest that non-conventional MR techniques may be reliable outcome measures for clinical trials in MS.
Key wordsMultiple sclerosis Magnetic resonance imaging Magnetisation tranfer imaging Spinal cord Measurement reproducibility
Unable to display preview. Download preview PDF.
- 2.British Standards Institution (1979) Precision of test methods. I. Guide for the determination and reproducibility of a standard test method. British Standard 5497Google Scholar
- 11.Filippi M, Horsfield MA, Gasperini C, Waesberghe JH van, Gawne-Cain ML, Rocca MA, Bastianello S, Lycklama è Nijeholt GJ, Miller DH (1996) Inter-scanner variation in brain MRI lesion load measurement in multiple sclerosis. Proc Fourth Sci Meeting Int Soc Magn Reson Med 1:171Google Scholar
- 14.Gawne-Cain ML, Webb S, Tofts PS, Miller DH (1996) The effect of repositioning inaccuracies on intracranial MS lesion volume measurements (abstract). Proc Fourth Sci Meeting Int Soc Magn Reson Med 1:534Google Scholar
- 15.Grimaud J, Lai M, Thorpe JW, Adeleine P, Plummer D, Barker GJ, Wang L, Tofts PS, McDonald WI, Miller DH (1995) Evaluation of computer-assisted quantification of MS lesions in cranial MR imaging (abstract). Proc Third Sci Meeting Int Soc Magn Reson Med 1:283Google Scholar
- 19.Loevener LA, Grossman RI, McGowan JC, Ramer KN, Cohen JA (1995) Characterization of multiple sclerosis plaques with T1-weighted MR and quantitative magnetization transfer. AJNR 16:1473–1479Google Scholar
- 20.Losseff N, Lai M, Miller DH, McDonald WI, Thompson AJ (1995) The prognostic value of serial axial cord area measurement by magnetic resonance imaging in multiple sclerosis (abstract). J Neurol 242 [Suppl 2]: 110Google Scholar
- 26.Smith ME, Stone LA, Albert PS, Frank JA, Martin R, Armstrong M, Maloni H, McFarlin DE, McFarland HF (1993) Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions. Ann Neurol 33: 480–489CrossRefGoogle Scholar