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Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential

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Abstract

Stroke, a global disease with a high disability rate, has limited options for functional rehabilitation and results in an adverse impact on patients’ lives. In recent years, mesenchymal stem cells (MSCs) have become a new focus of treatment owing to their potential for neuroregeneration. MSCs have demonstrated therapeutic efficacy capable of cell migration, angiogenesis, immunomodulation, neuroprotection and neural circuit reconstruction. The paracrine action of MSCs can also exert neurotrophic effects and improve the functional recovery. This review shows the transplantation protocol for MSCs, discusses the potential therapeutic mechanisms, and summarizes clinical trials on MSCs for treating ischemic stroke. The current proofs show that MSC therapy for ischemic stroke is safe and feasible. The timing and optimal dose of MSC administration are the main challenges in its clinical use. Although still under research, MSC therapy has the potential to be a new therapeutic approach for neurological recovery from ischemic stroke in the future.

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Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Lu 119, Fengtai District, Beijing, 100070, China

    Junsheng Li, Qian Zhang, Wen Wang, Fa Lin, Shuo Wang & Jizong Zhao

  2. China National Clinical Research Center for Neurological Diseases, Beijing, China

    Junsheng Li, Qian Zhang, Wen Wang, Fa Lin, Shuo Wang & Jizong Zhao

  3. Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China

    Junsheng Li, Qian Zhang, Wen Wang, Fa Lin, Shuo Wang & Jizong Zhao

  4. Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China

    Junsheng Li, Qian Zhang, Wen Wang, Fa Lin, Shuo Wang & Jizong Zhao

  5. Beijing Translational Engineering Center for 3D Printer in Clinical Neuroscience, Beijing, China

    Junsheng Li, Qian Zhang, Wen Wang, Fa Lin, Shuo Wang & Jizong Zhao

  6. Savaid Medical School, University of the Chinese Academy of Sciences, Beijing, China

    Jizong Zhao

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  1. Junsheng Li
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  2. Qian Zhang
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  3. Wen Wang
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  4. Fa Lin
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  5. Shuo Wang
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Correspondence to Jizong Zhao.

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This study was approved by the Institutional Review Board of Beijing Tiantan Hospital.

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Li, J., Zhang, Q., Wang, W. et al. Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential. J Neurol 268, 4095–4107 (2021). https://doi.org/10.1007/s00415-020-10138-5

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  • DOI: https://doi.org/10.1007/s00415-020-10138-5

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