Journal of Neurology

, Volume 266, Issue 12, pp 3160–3161 | Cite as

High-dose steroid therapy for CNS inflammatory diseases increases INR in patients taking oral vitamin K antagonist

  • Stefano Gelibter
  • Mario Orrico
  • Tommaso Croese
  • Luca Bosco
  • Vittorio Martinelli
  • Francesca Sangalli
  • Massimo FilippiEmail author
Letter to the Editors


Author contributions

Stefano Gelibter: acquisition and analysis of data, drafting the manuscript; Mario Orrico, Tommaso Croese, Luca Bosco, Vittorio Martinelli, Francesca Sangalli: acquisition and analysis of data, revising the manuscript; Massimo Filippi: revising the manuscript; study supervision.

Compliance with ethical standards

Conflicts of interest

Stefano Gelibter, Mario Orrico, Tommaso Croese, Luca Bosco, Vittorio Martinelli, and Francesca Sangalli have nothing to disclose. Massimo Filippi is Editor-in-Chief of the Journal of Neurology; received compensation for consulting services and/or speaking activities from Biogen Idec, Merck-Serono, Novartis, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Merck-Serono, Novartis, Teva Pharmaceutical Industries, Roche, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA).

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee and the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.


  1. 1.
    Kaufman M (1997) Treatment of multiple sclerosis with high-dose corticosteroids may prolong the prothrombin time to dangerous levels in patients taking warfarin. Mult Scler 3:248–249CrossRefGoogle Scholar
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    Costedoat-Chalumeau N, Amoura Z, Aymard G et al (2000) Potentiation of Vitamin K antagonists by high-dose intravenous methylprednisolone. Ann Intern Med 132:631–635CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Neurology UnitIRCCS San Raffaele Scientific InstituteMilanItaly
  2. 2.Neuroimaging Research Unit, Institute of Experimental Neurology, Division of NeuroscienceIRCCS San Raffaele Scientific InstituteMilanItaly
  3. 3.Vita-Salute San Raffaele UniversityMilanItaly

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