Benign paroxysmal positional vertigo in Meniere’s disease: systematic review and meta-analysis of frequency and clinical characteristics

  • Mansur A. KutlubaevEmail author
  • Ying Xu
  • Jeremy Hornibrook


There is a recognized association of Meniere’s disease (MD) and benign paroxysmal positional vertigo (BPPV). However, the frequency and clinical characteristics of BPPV in MD are unclear. The aim of this review was to determine the mean frequency and clinical features of BPPV in MD. Three databases were searched: MEDLINE, PubMed and Google Academia. Studies reporting the frequency of BPPV in MD were pooled. A total of 4198 references were identified, of which 20 studies were considered eligible. The pooled frequency of BPPV in MD was 14% (95% CI 9–18%). It was 38% (95% CI 26–49%) in longitudinal studies and 8% (95% CI 6–11%) in cross-sectional ones. BPPV comorbid with MD was mostly observed in the ear affected by hydrops, in females, in patients with more advanced disease. Canalolithiasis of the horizontal semicircular canal was more common in patients with BPPV associated with MD than in idiopathic BPPV. BPPV in MD was more prone to recurrence and required more canal repositioning maneuvers.


Benign paroxysmal positional vertigo Meniere’s disease Hydrops Otolithiasis Vertigo 


Compliance with ethical standards

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurologyBashkir State Medical UniversityUfaRussia
  2. 2.Department of NeurologyG.G. Kuvatov Republican Clinical HospitalUfaRussia
  3. 3.Sydney Medical SchoolUniversity of SydneySydneyAustralia
  4. 4.The George Institute for Global Health, Faculty of MedicineUniversity of New South WalesCamperdownAustralia
  5. 5.Department of Otolaryngology-Head and Neck Surgery and AudiologyChristchurch HospitalChristchurchNew Zealand

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