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Screening for cognitive impairment among patients with neuromyelitis optica using touchscreen cognitive testing in routine clinical care

  • Jack CotterEmail author
  • Fiona Trew
  • Shuna Colville
  • Dawn Lyle
  • Denise Cranley
  • Francesca Cormack
  • Jennifer H. Barnett
  • Katy Murray
  • Suvankar Pal
Letter to the Editors

Dear Sirs,

Neuromyelitis optica (NMO) is a rare autoimmune disease associated with inflammation of the optic nerves, spinal cord and brainstem [1]. In addition to physical and visual problems, cognitive dysfunction is also common among people with NMO (pwNMO) [2], but is potentially under-recognised and incompletely evaluated in routine clinical care. We aimed to investigate the spectrum of cognitive impairment in pwNMO presenting to a specialist clinic using a brief cognitive battery administered on a touchscreen tablet computer.

All pwNMO attending the Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, between February 2014 and February 2015 were offered the opportunity to complete the cognitive tasks as part of their routine holistic clinical assessment. Three tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) (assessing five different domains of cognition) were administered using a touchscreen tablet computer (iPad Air, Apple Inc.):
  1. 1.

    Matc...

Notes

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflicts of interest

JC, FC and JB are employees of Cambridge Cognition Ltd. The authors report no other conflicts of interest.

Ethics statement

The authors declare that they complied with ethical standards and the study was in accord with the Declaration of Helsinki.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Jack Cotter
    • 1
    Email author
  • Fiona Trew
    • 2
  • Shuna Colville
    • 3
    • 4
  • Dawn Lyle
    • 3
    • 4
  • Denise Cranley
    • 3
    • 4
  • Francesca Cormack
    • 1
  • Jennifer H. Barnett
    • 1
    • 5
  • Katy Murray
    • 3
    • 4
    • 6
  • Suvankar Pal
    • 3
    • 4
    • 6
  1. 1.Cambridge CognitionCambridgeUK
  2. 2.College of Medicine and Veterinary MedicineUniversity of EdinburghEdinburghUK
  3. 3.Anne Rowling Regenerative Neurology ClinicUniversity of EdinburghEdinburghUK
  4. 4.Centre for Clinical Brain SciencesUniversity of EdinburghEdinburghUK
  5. 5.Department of PsychiatryUniversity of CambridgeCambridgeUK
  6. 6.Forth Valley Royal HospitalLarbertUK

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