Can verapamil be effective in controlling vertigo and headache attacks in vestibular migraine accompanied with Meniere’s disease? A preliminary study
- 77 Downloads
Several studies have pointed to an association between migraine, vestibular migraine (VM) and Meniere’s Disease (MD) [1, 2, 3, 4, 5, 6, 7]. Though the underlying link is not clear they seem to be parts of a broad spectrum disorder  and can share a common genetic basis to confer susceptibility . “VM/MD overlapping syndrome” diagnosis has been proposed for patients presenting with simultaneous symptoms/signs of VM and MD .
Depending on clinical similarities with episodic ataxia type 2 and familial hemiplegic migraine, voltage-dependent calcium channel gene (CACNA1A) mutations have been searched in patients with VM, but could not be identified [8, 9]. Potassium channel mutations  and the role of aquaporins in inner ear water homeostasis  have been speculated in MD pathophysiology.
Based on these speculations, we tried to analyze the efficacy of verapamil, a calcium channel blocker in controlling vertigo and headache attacks of patients with VM associated with...
Compliance with ethical standards
Conflicts of interest
No conflict of interest.
All procedures were performed in accordance with the ethical standards stated in the Declaration of Helsinki and its later amendments.
- 4.Neff BA, Staab JP, Eggers SD, Carlson ML, Schmitt WR, Van Abel KM, Worthington DK, Beatty CW, Driscoll CL, Shepard NT (2012) Auditory and vestibular symptoms and chronic subjective dizziness in patients with Meniere’s disease, vestibular migraine, and Meniere’s disease with concomitant vestibular migraine. Otol Neurotol 33:1235–1244CrossRefGoogle Scholar
- 13.Lopez-Escamez JA, Carey J et al (2015) Diagnostic criteria for Menière’s disease. J Vest Res 25:1–7Google Scholar