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Anger, hostility and risk of stroke: a meta-analysis of cohort studies

  • Hanze Chen
  • Beidi Zhang
  • Weishuang Xue
  • Jinwei Li
  • Yuru Li
  • Kailei Fu
  • Xinxin Chen
  • Miao Sun
  • Han Shi
  • Li TianEmail author
  • Weiyu TengEmail author
Original Communication

Abstract

Objective

A growing number of studies have been conducted on the relationship between anger and hostility and the risk of stroke, and their conclusions are not consistent. Accordingly, we performed a meta-analysis to evaluate the relationship between anger and hostility and the risk of stroke.

Methods

We searched the PubMed and Embase databases for cohort studies, focusing on the relationship between anger and hostility and risk of stroke. Then studies were selected according to the inclusion and exclusion criteria. Study results were pooled using a random effects model.

Results

Ten studies from seven articles involving 52,277 participants were included in this meta-analysis. No significant association was found between anger and hostility level and risk of stroke (hazard ratio 1.08; 95% confidence interval 0.79–1.47). However, a positive association was seen when people with high socioeconomic status were excluded (hazard ratio 1.30; 95% confidence interval 1.06–1.59).

Conclusion

A higher level of anger and hostility is not associated with elevated risk of stroke. However, the association is positive among people with lower socioeconomic status.

Keywords

Stroke Anger Hostility Cohort studies Meta-analysis 

Notes

Acknowledgements

This work was supported by a National Science and Technology Major Project (2017ZX10201101) and a China Medical University Major Clinical Medicine Construction Project in 2018 (111-3110118036).

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical standards

This manuscript does not contain clinical studies or patient data.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Hanze Chen
    • 1
  • Beidi Zhang
    • 2
  • Weishuang Xue
    • 1
  • Jinwei Li
    • 1
  • Yuru Li
    • 1
  • Kailei Fu
    • 1
  • Xinxin Chen
    • 1
  • Miao Sun
    • 1
  • Han Shi
    • 3
  • Li Tian
    • 4
    Email author
  • Weiyu Teng
    • 1
    Email author
  1. 1.Department of Neurology, The First Affiliated HospitalChina Medical UniversityShenyangChina
  2. 2.Department of Endodontics, School of StomatologyChina Medical UniversityShenyangChina
  3. 3.Clinical Department OneChina Medical UniversityShenyangChina
  4. 4.Department of Geriatrics, Shengjing HospitalChina Medical UniversityShenyangChina

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