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Incidence of Parkinson’s disease in a large patient cohort with idiopathic smell and taste loss

  • Antje Haehner
  • Carla Masala
  • Sophie Walter
  • Heinz Reichmann
  • Thomas Hummel
Original Communication
  • 56 Downloads

Abstract

Introduction

Patients with idiopathic smell loss constitute an at-risk population for the development of Parkinson’s disease (PD). The study aimed to follow up a large number of patients with idiopathic smell and/or taste loss to define the incidence of PD in this population and, further, to assess characteristics of both olfactory and gustatory function and their possible association with PD development.

Methods

In this prospective case–control study, 833 patients diagnosed with an idiopathic smell disorder at our Smell and Taste Center during the last 15 years were contacted for a telephone interview. In 474 patients, a complete data set containing of demographic data, clinical information, retrospective smell and taste testing results, and telephone assessment was obtained.

Results

Out of 474 patients with idiopathic smell loss 45 (9.8%) had been diagnosed with PD, since they received the diagnosis of idiopathic smell and/or taste loss (mean 10.9 years after olfactory loss onset). Thus, with respect to the classification into olfactory/gustatory disorders, 28.6% of the patients with a combined olfactory and gustatory disorder developed PD, whereas in 9.9% of those with a pure olfactory disorder and in 3.8% of those with a pure gustatory disorder, PD was diagnosed. No association emerged between qualitative smell or taste loss and PD development.

Conclusion

This large patient cohort study extends the previous literature, indicating that risk stratification might be considerably improved by correct diagnostic allocation and emphasizes the need for an exhaustive olfactory and gustatory assessment in specialized centers.

Keywords

Idiopathic smell loss Idiopathic taste loss Parkinson’s disease 

Notes

Acknowledgements

We thank Prof. Ilona Croy for assistance with data analysis.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Hawkes CH, Del Tredici K, Braak H (2010) A timeline for Parkinson’s disease. Parkinsonism Relat Disord 16:79–84CrossRefGoogle Scholar
  2. 2.
    Berendse HW, Roos DS, Raijmakers P, Doty RL (2011) Motor and non-motor correlates of olfactory dysfunction in Parkinson’s disease. J Neurol Sci 310:21–24CrossRefGoogle Scholar
  3. 3.
    Doty RL, Deems DA, Stellar S (1988) Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 38:1237–1244CrossRefGoogle Scholar
  4. 4.
    Hawkes CH, Shephard BC, Daniel SE (1997) Olfactory dysfunction in Parkinson’s disease. J Neurol Neurosurg Psychiatry 62(5):436–446CrossRefGoogle Scholar
  5. 5.
    Haehner A, Boesveldt S, Berendse HW, Mackay-Sim A, Fleischmann J, Silburn PA et al (2009) Prevalence of smell loss in Parkinson’s disease—a multicenter study. Park Relat Disord 15:490–494CrossRefGoogle Scholar
  6. 6.
    Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W et al (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30(12):1591–1601CrossRefGoogle Scholar
  7. 7.
    Braak H, Del Tredici K, Rub U, de Vos RAI, Jansen Steur ENH, Braak H (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24:197–211CrossRefGoogle Scholar
  8. 8.
    Iannilli E, Stephan L, Hummel T, Reichmann H, Haehner A (2017) Olfactory impairment in Parkinson’s disease is a consequence of central nervous system decline. J Neurol 264(6):1236–1246CrossRefGoogle Scholar
  9. 9.
    Witt M, Bormann K, Gudziol V, Pehlke K, Barth K, Minovi A et al (2009) Biopsies of olfactory epithelium in patients with Parkinson’s disease. Mov Disord 24(6):906–914CrossRefGoogle Scholar
  10. 10.
    Ponsen MM, Stoffers D, Booij J, van Eck-Smit BLF, Wolters EC, Berendse HW (2004) Idiopathic hyposmia as a preclinical sign of Parkinson’s disease. Ann Neurol 56:173–181CrossRefGoogle Scholar
  11. 11.
    Ponsen MM, Stoffers D, Twisk JW, Wolters ECH, Berendse HW (2009) Hyposmia and executive dysfunction as predictors of future Parkinson’s disease: a prospective study. Mov Disord 24(7):1060–1065CrossRefGoogle Scholar
  12. 12.
    Haehner A, Hummel T, Hummel C, Sommer U, Junghanns S, Reichmann H (2007) Olfactory loss may be a first sign of idiopathic Parkinson’s disease. Mov Disord 22:839–842CrossRefGoogle Scholar
  13. 13.
    Ross GW, Petrovitch H, Abbott RD, Tanner CM, Popper J, Masaki K et al (2008) Association of olfactory dysfunction with risk for future Parkinson’s disease. Ann Neurol 63:167–173CrossRefGoogle Scholar
  14. 14.
    Berg D, Godau J, Seppi K, Behnke S, Liepelt-Scarfone I, Lerche S et al (2013) The PRIPS study: screening battery for subjects at risk for Parkinson’s disease. Eur J Neurol 20(1):102–108CrossRefGoogle Scholar
  15. 15.
    Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) ‘Sniffin’ Sticks’: olfactory performance assessed by the combined testing of odour identification, odour discrimination and olfactory threshold. Chem Senses 22:39–52CrossRefGoogle Scholar
  16. 16.
    Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the ‘‘Sniffin’ Sticks’’ including tests of odour identification, odour discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243CrossRefGoogle Scholar
  17. 17.
    Landis BN, Welge-Luessen A, Bramerson A, Bende M, Mueller CA, Nordin S et al (2009) “Taste Strips”—a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol 256:242–248CrossRefGoogle Scholar
  18. 18.
    Gaig C, Tolosa E (2009) When does Parkinson’s disease begin? Mov Disord 24(Suppl 2):S656–S664CrossRefGoogle Scholar
  19. 19.
    Morrish PK, Rakshi JS, Bailey DL, Sawle GV, Brooks DJ (1998) Measuring the rate of progression and estimating the preclinical period of Parkinson’s disease with [18F]dopa PET. J Neurol Neurosurg Psychiatry 64:314–319CrossRefGoogle Scholar
  20. 20.
    Marek K, Jennings D (2009) Can we image premotor Parkinson disease? Neurology 72(Suppl 7):S21–S26CrossRefGoogle Scholar
  21. 21.
    Gaenslen A, Swid I, Liepelt-Scarfone I, Godau J, Berg D (2011) The patients’ perception of prodromal symptoms before the initial diagnosis of Parkinson’s disease. Mov Disord 26(4):653–658CrossRefGoogle Scholar
  22. 22.
    Pont-Sunyer C, Hotter A, Gaig C, Seppi K, Compta Y, Katzenschlager R et al (2015) The onset of nonmotor symptoms in Parkinson’s disease (the ONSET PD study). Mov Disord 30(2):229–237CrossRefGoogle Scholar
  23. 23.
    Chen H, Shrestha S, Huang X, Jain S, Guo X, Tranah GJ, Garcia ME, Satterfield S, Phillips C, Harris TB, Health ABC Study (2017) Olfaction and incident Parkinson disease in US white and black older adults. Neurology 89(14):1441–1447CrossRefGoogle Scholar
  24. 24.
    Mahlknecht P, Kiechl S, Willeit J, Poewe W, Seppi K (2018) Reader response: olfaction and incident Parkinson disease in US white and black older adults. Neurology 90(20):940CrossRefGoogle Scholar
  25. 25.
    Landis BN, Reden J, Haehner A (2010) Idiopathic phantosmia: outcome and clinical significance. ORL 72:252–255CrossRefGoogle Scholar
  26. 26.
    Kashihara K, Hanaoka A, Imamura T (2011) Frequency and characteristics of taste impairment in patients with Parkinson’s disease: results of a clinical interview. Intern Med 50:2311–2315CrossRefGoogle Scholar
  27. 27.
    Sienkiewicz-Jarosz H, Scinska A, Kuran W, Ryglewicz D, Rogowski A, Wrobel E et al (2005) Taste responses in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 76:40–46CrossRefGoogle Scholar
  28. 28.
    Lang CJG, Leuschner T, Ulrich K, Stössel C, Heckmann JG, Hummel T (2006) Taste in dementing diseases and parkinsonism. J Neurol Sci 248:177–184CrossRefGoogle Scholar
  29. 29.
    Shah M, Deeb J, Fernando M, Noyce A, Visentin E, Findley LJ et al (2009) Abnormality of taste and smell in Parkinson’s disease. Parkinsonism Relat Disord 15:232–237CrossRefGoogle Scholar
  30. 30.
    Deeb J, Shah M, Muhammed N, Gunasekera R, Gannon K, Findley LJ et al (2010) A basic smell test is a sensitive as dopamine transporter scan: comparison of olfaction, taste and DaTSCAN in the diagnosis of Parkinson’s disease. QJMed 103:941–952CrossRefGoogle Scholar
  31. 31.
    Kim H-J, Jeon BS, Lee J-Y, Cho Y-J, Hong K-S, Cho J-Y (2011) Taste function in patients with Parkinson disease. J Neurol 258:1076–1079CrossRefGoogle Scholar
  32. 32.
    Cecchini MP, Osculati F, Ottaviani S, Boschi F, Fasano A, Tinazzi M (2014) Taste performance in Parkinson’s disease. J Neural Transm 121:119–122CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology, Smell and Taste ClinicTU DresdenDresdenGermany
  2. 2.Section of Physiology, Department of Biomedical SciencesUniversity of CagliariCagliariItaly
  3. 3.Department of NeurologyTU DresdenDresdenGermany

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