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Journal of Neurology

, Volume 266, Issue 1, pp 157–164 | Cite as

Non-invasive evaluation of cerebral perfusion in patients with transient ischemic attack: an fMRI study

  • Yating Lv
  • Wei Wei
  • Yulin Song
  • Yu Han
  • Chengshu Zhou
  • Dan Zhou
  • Fuding Zhang
  • Qiming Xue
  • Jinling Liu
  • Lijuan Zhao
  • Cairong Zhang
  • Lingyu Li
  • Yu-Feng Zang
  • Xiujie HanEmail author
Original Communication

Abstract

Detection of hypoperfused tissue due to the ischemia is considered to be important in understanding the cerebral perfusion status and may be helpful in guiding therapeutic decisions for patients with transient ischemic attack (TIA). We hypothesized that the combination of two non-invasive fMRI techniques: resting-state BOLD-fMRI time-shift analysis (TSA) approach and 3D ASL, could detect the cerebral hemodynamic status in TIA patients noninvasively. From April 2015 to June 2016, 51 TIA patients were recruited in this study. We calculated the time delay between the resting-state BOLD signal at each voxel and the whole-brain signal using TSA approach and compared the results to CBF map derived from ASL. Out of the 51 patients, 24 patients with normal arrival time and CBF were in Stage 0; 14 patients who showed delayed arrival time and normal CBF which indicated elevated CBV were in Stage I; the other 13 patients who had both delayed arrival time and decreased CBF were in Stage II, the group average spatial overlap, i.e., Dice coefficient, of the two measurements was 0.55. Four patients in Stage 0 (17.4%), three patients in Stage I (23.1%) and five patients in Stage II (45.5%) suffered ischemic stroke or TIA symptoms in 1 year after MRI scan. The patients in Stage II was at highest risk of subsequent events when compared to other two stages. The combination of resting-state BOLD-fMRI and ASL hold the potential to noninvasively identify the hemodynamic status in TIA patients and help predict the risk of subsequent events.

Keywords

Perfusion Resting-state fMRI Arterial spin labeling Time-shift analysis Transient ischemic attack Cerebral blood flow 

Notes

Acknowledgements

We thank two professional radiologists (Ni Ling and Chen Qian) for helping delineate the data. We thank all the patients and volunteers for participating in this study. This work was supported by grants from National Key R&D Program of China (No. 2017YFC1310000), National Natural Science Foundation of China (No. 81771911, 81301210, 81271652, 81520108016, 31471084, 81661148045), Dr. Zang is partly supported by “Qian Jiang Distinguished Professor” program.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical standards

This study was approved by the Ethics Committee of the Center for Cognition and Brain Disorders, Hangzhou Normal University. Written informed consent was obtained from each participant.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yating Lv
    • 1
    • 2
    • 3
  • Wei Wei
    • 1
    • 2
    • 3
  • Yulin Song
    • 3
  • Yu Han
    • 4
  • Chengshu Zhou
    • 3
  • Dan Zhou
    • 3
  • Fuding Zhang
    • 3
  • Qiming Xue
    • 5
  • Jinling Liu
    • 6
  • Lijuan Zhao
    • 3
  • Cairong Zhang
    • 3
  • Lingyu Li
    • 1
    • 2
    • 3
  • Yu-Feng Zang
    • 1
    • 2
    • 3
  • Xiujie Han
    • 3
    Email author
  1. 1.Institutes of Psychological SciencesHangzhou Normal UniversityHangzhouChina
  2. 2.Zhejiang Key Laboratory for Research in Assessment of Cognitive ImpairmentsHangzhouChina
  3. 3.Department of NeurologyAnshan Changda HospitalAnshanChina
  4. 4.Department of Neurologythe First Affiliated Hospital, Dalian Medical UniversityDalianChina
  5. 5.Department of ImageAnshan Changda HospitalAnshanChina
  6. 6.Department of UltrasonicsAnshan Changda HospitalAnshanChina

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