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Journal of Neurology

, Volume 265, Issue 10, pp 2322–2332 | Cite as

Impaired brain response to odors in patients with varied severity of olfactory loss after traumatic brain injury

  • Pengfei Han
  • Nicole Winkler
  • Cornelia Hummel
  • Antje Hähner
  • Johannes Gerber
  • Thomas Hummel
Original Communication
  • 134 Downloads

Abstract

Traumatic brain injury (TBI) as a major public health problem may lead to olfactory dysfunction. However, little is known about brain responses to odors in TBI olfactory loss patients. Nineteen healthy controls and forty TBI olfactory dysfunctional patients (19 with hyposmia and 21 with anosmia) underwent a functional magnetic resonance imaging scan when two odors (peach and coffee) were presented intranasally using a computerized olfactometer. Olfactory performance was measured using the “Sniffin’ Sticks” test. TBI patients with hyposmia or anosmia showed decreased odor-induced brain activations in the primary olfactory area and insular cortex as compared to healthy controls (FWE-corrected peak p < 0.05). In addition, negative correlations were found between the time since injury (in month) and odor-induced brain responses in the right primary olfactory area for patients with hyposmia. Similar correlations were seen in the insula and orbitofrontal cortex for patients with anosmia. In conclusion, results from the current study are evidences for the impairment of central nervous processing of odor perception at all levels of the olfactory system among TBI patients with olfactory loss. In addition, the duration after the initial injury may have an impact on the severity of olfactory dysfunction.

Keywords

Traumatic brain injury Olfaction dysfunction Odor Functional magnetic resonance imaging Time since injury 

Notes

Acknowledgements

We would like to thank Claudia Valder, Frey und Lau, Henstedt-Ulzburg, Germany, for an excellent collaboration and donation of the odors. This research as supported by a Grant from the Deutsche Forschungsgemeinschaft to TH (DFG HU 411/18 − 1).

Compliance with ethical standards

Conflicts of interest

None of the authors has a potential conflict of interest.

Ethical standard

The study design was approved by the local Ethics Committee.

Supplementary material

415_2018_9003_MOESM1_ESM.docx (19 kb)
Supplementary material 1 (DOCX 19 KB)
415_2018_9003_MOESM2_ESM.doc (110 kb)
Supplementary material 2 (DOC 110 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of OtorhinolaryngologyTU DresdenDresdenGermany
  2. 2.Department of NeuroradiologyTU DresdenDresdenGermany

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