Journal of Neurology

, Volume 265, Issue 9, pp 2143–2145 | Cite as

Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study

  • José Berciano
  • Nuria Terán-Villagrá
Letter to the Editors

Dear Sirs,

Sneddon syndrome (SS) is a non-inflammatory thrombotic arteriopathy characterized by the combination of cerebrovascular disease and livedo racemosa (LR) [1, 2, 3]. SS is now regarded as a common manifestation of different disease entities, namely: (1) idiopathic SS with neither antiphospholipid antibodies (aPL) nor coexisting systemic lupus erythematosus (SLE); (2) primary antiphospholipid syndrome (APS)-related SS; (3) SLE-related SS with or without aPL. Autopsy studies are scanty [4, 5, 6]. Here, we describe the full clinicopathological study of an SS patient with marantic endocarditis, who was included as case 4 in our idiopathic SS series collected between 1977 and 1981 [1].

This right-handed patient was admitted in 1980, at age 53, with a 4-year history of progressive cognitive decline. At ages 39 and 52, she had experienced two sudden and reversible episodes of right hemiparesis. There was generalized LR (Fig. 1a) [7]. She had seven pregnancies all of them ending in...


Compliance with ethical standards

Conflicts of interest

The authors declare that we have no conflict of interest.

Ethical standards

This study was performed in accordance with ethical standards.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Service of Neurology, University Hospital “Marqués de Valdecilla (IDIVAL)”University of Cantabria, and “Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)”SantanderSpain
  2. 2.Department of Medicine and Psychiatry, “Edificio Escuela Universitaria de Enfermería (cuarta planta)”University of CantabriaSantanderSpain
  3. 3.Service of Pathology, University Hospital “Marqués de Valdecilla (IDIVAL)”University of CantabriaSantanderSpain

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