Journal of Neurology

, Volume 265, Issue 3, pp 688–700 | Cite as

Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson’s disease

  • Kazuya Kawabata
  • Hirohisa Watanabe
  • Kazuhiro Hara
  • Epifanio Bagarinao
  • Noritaka Yoneyama
  • Aya Ogura
  • Kazunori Imai
  • Michihito Masuda
  • Takamasa Yokoi
  • Reiko Ohdake
  • Yasuhiro Tanaka
  • Takashi Tsuboi
  • Tomohiko Nakamura
  • Masaaki Hirayama
  • Mizuki Ito
  • Naoki Atsuta
  • Satoshi Maesawa
  • Shinji Naganawa
  • Masahisa Katsuno
  • Gen Sobue
Original Communication


Cognitive deficits in Parkinson’s disease (PD) are heterogeneous entities, but a relationship between the heterogeneity of cognitive deficits and resting-state network (RSN) changes remains elusive. In this study, we examined five sub-domain scores according to Addenbrooke’s Cognitive Examination-Revised (ACE-R) for the cognitive evaluation and classification of 72 non-demented patients with PD. Twenty-eight patients were classified as PD with normal cognition (PD-NC). The remaining 44 were subdivided into the following 2 groups using a hierarchical cluster analysis: 20 with a predominant decrease in memory (PD with amnestic cognitive deficits: PD-A) and 24 with good memory who exhibited a decrease in other sub-domains (PD with non-amnestic cognitive deficits: PD-NA). We used an independent component analysis of RS-fMRI data to investigate the inter-group differences of RSN. Compared to the controls, the PD-A showed lower FC within the ventral default mode network (vDMN) and the visuospatial network. On the other hand, the PD-NA showed lower FC within the visual networks and the cerebellum–brainstem network. Significant differences in the FC within the vDMN and cerebellum–brainstem network were observed between the PD-A and PD-NA, which provided a good discrimination between PD-A and PD-NA using a support vector machine. Distinct patterns of cognitive deficits correspond to different RSN changes.


Parkinson’s disease Cognitive deficits Resting-state fMRI Independent component analysis Resting-state network Functional connectivity 



This study was partially supported by a Grant-in-Aid from the Research Committee of Central Nervous System Degenerative Diseases by the Ministry of Health, Labour, and Welfare, Integrated Research on Neuropsychiatric Disorders project carried out Strategic Research Program for Brain Sciences (SRPBS), a Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control 26117002) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, as well as Integrated Research on neuropsychiatric disorders carried out under the SRPBS, Scientific Research on Innovative Areas (Comprehensive Brain Science Network), and Integrated Research on Depression, Dementia and Development Disorders by SRPBS from Japan Agency for Medical Research and development.

Compliance with ethical standards

Conflicts of interest

All authors declared no conflict of interest.

Ethical standards

This study conformed to the Ethical Guidelines for Medical and Health Research Involving Human Subjects endorsed by the Japanese government and was approved by the Ethics Committee of Nagoya University Graduate School of Medicine.

Supplementary material

415_2018_8755_MOESM1_ESM.docx (1.2 mb)
Supplementary material 1 (DOCX 1201 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Kazuya Kawabata
    • 1
    • 2
  • Hirohisa Watanabe
    • 1
    • 2
  • Kazuhiro Hara
    • 1
  • Epifanio Bagarinao
    • 2
  • Noritaka Yoneyama
    • 3
  • Aya Ogura
    • 1
  • Kazunori Imai
    • 1
  • Michihito Masuda
    • 1
  • Takamasa Yokoi
    • 1
  • Reiko Ohdake
    • 2
  • Yasuhiro Tanaka
    • 1
  • Takashi Tsuboi
    • 1
  • Tomohiko Nakamura
    • 1
  • Masaaki Hirayama
    • 4
  • Mizuki Ito
    • 1
  • Naoki Atsuta
    • 1
  • Satoshi Maesawa
    • 5
  • Shinji Naganawa
    • 6
  • Masahisa Katsuno
    • 1
  • Gen Sobue
    • 2
    • 7
  1. 1.Department of NeurologyNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Brain and Mind Research CenterNagoya UniversityNagoyaJapan
  3. 3.Department of NeurologyHanda City HospitalHandaJapan
  4. 4.Department of Pathophysiological Laboratory SciencesNagoya University Graduate School of MedicineNagoyaJapan
  5. 5.Department of NeurosurgeryNagoya University Graduate School of MedicineNagoyaJapan
  6. 6.Department of RadiologyNagoya University Graduate School of MedicineNagoyaJapan
  7. 7.Research Division of Dementia and Neurodegenerative DiseaseNagoya University Graduate School of MedicineNagoyaJapan

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