Journal of Neurology

, Volume 264, Issue 3, pp 591–594 | Cite as

Adverse clinical outcomes after dabigatran reversal with idarucizumab to facilitate acute stroke thrombolysis

  • Felix C. Ng
  • James Bice
  • Anne Rodda
  • Matthew Lee-Archer
  • Douglas E. Crompton
Letter to the Editors

Dear Sirs,

Intravenous tissue plasminogen activator (tPA) thrombolysis remains the only proven pharmacological treatment for acute ischemic stroke [1]. A common clinical scenario is where a patient with atrial fibrillation (AF) on therapeutic anticoagulation presents with an acute ischemic stroke but thrombolysis is absolutely contraindicated due to hemorrhagic risk.

Recently, dabigatran reversal with idarucizumab to facilitate thrombolysis in acute stroke patients on dabigatran has been proposed [ 2]. We present two patients, the first outside Europe, managed with this approach (Fig.  1).


Dabigatran Acute Ischemic Stroke Perfusion Compute Tomography Hemispheric Stroke Hemispheric Infarct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with ethical standards

Consent for case reports

Written consents were obtained by patient and families.

Conflicts of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Felix C. Ng
    • 1
  • James Bice
    • 1
  • Anne Rodda
    • 1
  • Matthew Lee-Archer
    • 1
  • Douglas E. Crompton
    • 1
  1. 1.Department of Neurology, Northern HealthEpping, MelbourneAustralia

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