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Journal of Neurology

, Volume 264, Issue 2, pp 333–340 | Cite as

Cardiac parasympathetic dysfunction in the early phase of Parkinson’s disease

  • Masashi Suzuki
  • Tomohiko NakamuraEmail author
  • Masaaki Hirayama
  • Miki Ueda
  • Masahisa Katsuno
  • Gen SobueEmail author
Original Communication

Abstract

Cardiac parasympathetic function is strongly affected by aging. Although sympathetic dysfunction has been well documented in Parkinson’s disease (PD), cardiac parasympathetic dysfunction has not been well studied. The objective of this study was to clarify the development of cardiac parasympathetic dysfunction in the early phase of PD and to explore the age-corrected correlation between cardiac parasympathetic dysfunction and cardiac sympathetic dysfunction. We reviewed 25 healthy controls and 56 patients with idiopathic PD of Hoehn and Yahr stages I–III. We evaluated cardiac parasympathetic function using the Valsalva ratio, the baroreflex sensitivity (BRS) and the coefficient of variation of RR intervals in the resting state (resting-CVRR) and during deep breathing (DB-CVRR). In addition, we measured cardiac 123I-metaiodobenzylguanidine (MIBG) uptake to investigate the relationship between cardiac sympathetic and parasympathetic dysfunction in PD. Compared with healthy controls, patients with PD showed significantly decreased cardiac parasympathetic parameters (resting-CVRR 2.8 ± 1.3 vs. 1.7 ± 0.6%, p < 0.001; DB-CVRR 5.8 ± 2.3 vs. 3.8 ± 1.7%, p < 0.001; Valsalva ratio 1.52 ± 0.26 vs. 1.34 ± 0.17, p < 0.01; BRS 10.6 ± 9.5 vs. 5.0 ± 5.4 ms/mmHg, p < 0.01). In particular, resting-CVRR and DB-CVRR were significantly decreased in the early phase of PD. In age-corrected analyses, none of the parasympathetic indices correlated with the delayed cardiac 123I-MIBG uptake. These observations indicate that cardiac parasympathetic dysfunction occurs in the early phase of PD, but not necessarily in parallel with cardiac sympathetic dysfunction.

Keywords

Parkinson’s disease Cardiac parasympathetic dysfunction Cardiac 123I-metaiodobenzylguanidine scintigraphy Autonomic dysfunction Autonomic nervous system 

Notes

Compliance with ethical standards

Funding sources

This work was supported by JSPS KAKENHI Grant Nos. JP24590691, JP16K09713; and Grants from the Ministry of Health, Labor and Welfare of Japan.

Financial disclosure/conflicts of interest

None of the authors reports any financial interests or potential conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of NeurologyNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Department of Pathophysiological Laboratory ScienceNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Research Division of Dementia and Neurodegeneration DiseaseNagoya University Graduate School of MedicineNagoyaJapan

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