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Journal of Neurology

, Volume 264, Issue 6, pp 1035–1050 | Cite as

Vaccines and multiple sclerosis: a systematic review

  • Mia Topsøe Mailand
  • Jette Lautrup Frederiksen
Review

Abstract

Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles–mumps–rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.

Keywords

Multiple sclerosis Vaccination Immunization 

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Mia Topsøe Mailand
    • 1
  • Jette Lautrup Frederiksen
    • 2
  1. 1.University of CopenhagenCopenhagenDenmark
  2. 2.Department of NeurologyUniversity of Copenhagen, Rigshospitalet GlostrupGlostrupDenmark

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