Journal of Neurology

, Volume 264, Issue 3, pp 432–436 | Cite as

Thrombectomy for ischemic stroke: meta-analyses of recurrent strokes, vasospasms, and subarachnoid hemorrhages

  • Robert EmprechtingerEmail author
  • Brigitte Piso
  • Peter A. Ringleb


Mechanical thrombectomy with stent retrievers is an effective treatment for patients with ischemic stroke. Results of recent meta-analyses report that the treatment is safe. However, the endpoints recurrent stroke, vasospasms, and subarachnoid hemorrhage have not been evaluated sufficiently. Hence, we extracted data on these outcomes from the five recent thrombectomy trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA published in 2015). Subsequently, we conducted meta-analyses for each outcome. We report the results of the fixed, as well as the random effects model. Three studies reported data on recurrent strokes. While the results did not reach statistical significance in the random effects model (despite a three times elevated risk), the fixed effects model revealed a significantly higher rate of recurrent strokes after thrombectomy. Four studies reported data on subarachnoid hemorrhage. The higher pooled rates in the intervention groups were statistically significant in both, the fixed and the random effects model. One study reported on vasospasms. We recorded 14 events in the intervention group and none in the control group. The efficacy of mechanical thrombectomy is not questioned, yet our results indicate an increased risk for recurrent strokes, subarachnoid hemorrhage, and vasospasms post-treatment. Therefore, we strongly recommend a thoroughly surveillance, concerning these adverse events in future clinical trials and routine registries.


Thrombectomy Adverse events complication Recurrent event Vasospasm Subarachnoid hemorrhage 


Compliance with ethical standards

The manuscript does not contain clinical studies or patient data.

Conflicts of interest

Robert Emprechtinger: None. Brigitte Piso: None. Peter A Ringleb: received honoraria for advisory board participation from Boehringer Ingelheim and Covidien and lecture fee and travel support from Boehringer Ingelheim, Bayer, Pfizer, and Daiichi Sanyo.



Supplementary material

415_2016_8205_MOESM1_ESM.docx (46 kb)
Supplementary material 1 (DOCX 46 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Ludwig Boltzmann Institute for Health Technology AssessmentViennaAustria
  2. 2.Department of NeurologyUniversity Hospital HeidelbergHeidelbergGermany

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