Journal of Neurology

, Volume 263, Issue 1, pp 89–99 | Cite as

The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment

  • Geon Ha Kim
  • Sang Won Seo
  • Kihyo Jung
  • Oh-Hun Kwon
  • Hunki Kwon
  • Jong Hun Kim
  • Jee Hoon Roh
  • Min-Jeong Kim
  • Byung Hwa Lee
  • Doo Sang Yoon
  • Jung Won Hwang
  • Jong Min Lee
  • Jee Hyang Jeong
  • Heecheon You
  • Kenneth M. Heilman
  • Duk L. Na
Original Communication

Abstract

Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there are no studies exploring the neuroanatomical regions related to MID in SVCI patients. The aim of this study, therefore, was to investigate the neural correlates of MID in SVCI patients. Thirty-one patients with SVCI as well as 10 healthy match control participants were included. A “Pinch-Grip” apparatus was used to quantify the force control capabilities of the index finger in four different movement phases including initiation, development, maintenance, and termination. All participants underwent magnetic resonance imaging (MRI). Topographical cortical areas and white matter tracts correlated with the performances of the four different movement phases were assessed by the surface-based morphometry and tract-based spatial statistics analyses. Poorer performance in the maintenance task was related to cortical thinning in bilateral dorsolateral prefrontal, orbitofrontal and parietal cortices, while poorer performance in the termination task was associated with the disruption of fronto-parietal cortical areas as well as the white matter tracts including splenium and association fibers such as superior longitudinal fasciculus. Our study demonstrates that cortical areas and underlying white matter tracts associated with fronto-parietal attentional system play an important role in motor impersistence and perseveration in SVCI patients.

Keywords

Motor intentional disorder Subcortical vascular cognitive impairment Cortical thickness Tract-based spatial statistics 

Supplementary material

415_2015_7946_MOESM1_ESM.doc (45 kb)
Supplementary material 1 (DOC 45 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Geon Ha Kim
    • 1
    • 2
    • 3
  • Sang Won Seo
    • 2
    • 4
    • 5
  • Kihyo Jung
    • 6
  • Oh-Hun Kwon
    • 7
  • Hunki Kwon
    • 7
  • Jong Hun Kim
    • 8
  • Jee Hoon Roh
    • 9
  • Min-Jeong Kim
    • 10
  • Byung Hwa Lee
    • 2
    • 4
  • Doo Sang Yoon
    • 2
    • 4
  • Jung Won Hwang
    • 11
  • Jong Min Lee
    • 7
  • Jee Hyang Jeong
    • 1
  • Heecheon You
    • 12
  • Kenneth M. Heilman
    • 13
  • Duk L. Na
    • 2
    • 4
    • 14
  1. 1.Department of NeurologyEwha Womans University Mokdong Hospital, Ewha Womans University School of MedicineSeoulKorea
  2. 2.Department of NeurologySamsung Medical Center, Sungkyunkwan University School of MedicineSeoulKorea
  3. 3.Ewha Brain Institute, Ewha Womans UniversitySeoulKorea
  4. 4.Neuroscience Center, Samsung Medical CenterSeoulKorea
  5. 5.Department of Clinical Research Design and EvaluationSAIHST, Sungkyunkwan UniversitySeoulKorea
  6. 6.School of Industrial Engineering, University of UlsanUlsanKorea
  7. 7.Department of Biomedical EngineeringHanyang UniversitySeoulKorea
  8. 8.Department of Neurology, National Health Insurance CorporationIlsan HospitalGoyangKorea
  9. 9.Department of NeurologyAsan Medical Center, University of Ulsan College of MedicineSeoulKorea
  10. 10.Department of NeurologySeoul National University Hospital Healthcare System Gangnam CenterSeoulKorea
  11. 11.Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan UniversitySeoulKorea
  12. 12.Department of Industrial and Management EngineeringPohang University of Science and TechnologyPohangKorea
  13. 13.Department of NeurologyUniversity of Florida College of Medicine, and the Veterans Affairs Medical CenterGainesvilleUSA
  14. 14.Department of Health Sciences and TechnologySAIHST, Sungkyunkwan UniversitySeoulKorea

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