Journal of Neurology

, Volume 262, Issue 6, pp 1584–1586 | Cite as

Clinical and electroencephalographic on–off effect of amantadine in chronic non-traumatic minimally conscious state

  • A. EstraneoEmail author
  • A. Pascarella
  • P. Moretta
  • V. Loreto
  • L. Trojano
Letter to the Editors

Dear Sirs,

Positive effect of amantadine in promoting clinical recovery in patients with disorder of consciousness (DOC) has been extensively evaluated in patients with prolonged post-traumatic vegetative state or minimally conscious state (MCS) [1, 2, 3, 4, 5], whereas few studies investigated amantadine effect in non-traumatic DOC [6, 7], and only one reported on a chronic post-anoxic MCS patient [8].

Here, we describe the on–off effect of amantadine in a 57-year-old woman who had acutely developed severe intracranial hypertension due to a colloid cyst of the third ventricle. Twelve months post-onset the patient met criteria for diagnosis of MCS plus [9, 10], as confirmed by repeated clinical evaluation using the Coma Recovery Scale-Revised (CRS-R) [11, 12]. Repeated conventional electroencephalography (EEG) recordings at rest [13] showed a predominant background theta activity (7 Hz), with occasional low-frequency posterior alpha activity (8 Hz).

Sixteen months post-onset, after...


Amantadine Conscious State Minimally Conscious State Colloid Cyst Minimally Conscious State Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflicts of interest

The present research has not been sponsored by any commercial organization. The authors declare that they have no conflict of interest.

Ethical standard

The study was approved by the local Ethics Committee, and performed according to the ethical standards laid down in the 1964 Helsinki Declaration and its later amendments.

Informed consent

Written informed consent was obtained from the legal guardian of patient.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • A. Estraneo
    • 1
    Email author
  • A. Pascarella
    • 1
  • P. Moretta
    • 1
  • V. Loreto
    • 1
  • L. Trojano
    • 1
    • 2
  1. 1.Disorders of Consciousness Laboratory, Salvatore Maugeri FoundationIRCCS, Scientific Institute of Telese Terme (BN)Telese TermeItaly
  2. 2.Neuropsychology Laboratory, Department of PsychologySecond University of NaplesCasertaItaly

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