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Journal of Neurology

, Volume 261, Issue 11, pp 2093–2100 | Cite as

Testing the validity of a set of diagnostic criteria for sensory neuronopathies: a francophone collaborative study

  • Jean-Christophe AntoineEmail author
  • Florence Robert-Varvat
  • Thierry Maisonobe
  • Alain Créange
  • Jérôme Franques
  • Stéphane Mathis
  • Emilien Delmont
  • Thierry Kuntzer
  • Jean-Pascal Lefaucheur
  • Jean Pouget
  • Karine Viala
  • Claude Desnuelle
  • Andoni Echaniz-Laguna
  • Francesco Rotolo
  • Jean-Philippe Camdessanché
  • The French CIDP study group
Original Communication

Abstract

There are no validated criteria for the diagnosis of sensory neuronopathy (SNN) yet. In a preliminary monocenter study a set of criteria relying on clinical and electrophysiological data showed good sensitivity and specificity for a diagnosis of probable SNN. The aim of this study was to test these criteria on a French multicenter study. 210 patients with sensory neuropathies from 15 francophone reference centers for neuromuscular diseases were included in the study with an expert diagnosis of non-SNN, SNN or suspected SNN according to the investigations performed in these centers. Diagnosis was obtained independently from the set of criteria to be tested. The expert diagnosis was taken as the reference against which the proposed SNN criteria were tested. The set relied on clinical and electrophysiological data easily obtainable with routine investigations. 9/61 (16.4 %) of non-SNN patients, 23/36 (63.9 %) of suspected SNN, and 102/113 (90.3 %) of SNN patients according to the expert diagnosis were classified as SNN by the criteria. The SNN criteria tested against the expert diagnosis in the SNN and non-SNN groups had 90.3 % (102/113) sensitivity, 85.2 % (52/61) specificity, 91.9 % (102/111) positive predictive value, and 82.5 % (52/63) negative predictive value. Discordance between the expert diagnosis and the SNN criteria occurred in 20 cases. After analysis of these cases, 11 could be reallocated to a correct diagnosis in accordance with the SNN criteria. The proposed criteria may be useful for the diagnosis of probable SNN in patients with sensory neuropathy. They can be reached with simple clinical and paraclinical investigations.

Keywords

Sensory neuronopathy Sensory ganglionopathy Sensory neuropathy Paraneoplastic neurological syndrome Diagnostic criteria 

Notes

Conflicts of interest

This study was supported by a grant from the French Ministry of Health (PHRC Inter-Regional 2006 and 2010 API 28-01). None of the authors have financial relationship with the organization that sponsored the research.

Ethical standards

The study was approved by the Ethics Committee of the University Hospital of Saint-Etienne, France. For patients seen before 2011 being a retrospective non interventional study informed consent was not necessary while patients seen from 2011 onward signed an informed consent.

Supplementary material

415_2014_7423_MOESM1_ESM.pdf (42 kb)
Supplementary material 1 (PDF 42 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Jean-Christophe Antoine
    • 1
    • 2
    • 3
    • 11
    Email author
  • Florence Robert-Varvat
    • 1
  • Thierry Maisonobe
    • 4
  • Alain Créange
    • 5
  • Jérôme Franques
    • 6
  • Stéphane Mathis
    • 7
  • Emilien Delmont
    • 8
  • Thierry Kuntzer
    • 9
  • Jean-Pascal Lefaucheur
    • 5
  • Jean Pouget
    • 6
  • Karine Viala
    • 4
  • Claude Desnuelle
    • 8
  • Andoni Echaniz-Laguna
    • 10
  • Francesco Rotolo
    • 1
  • Jean-Philippe Camdessanché
    • 1
    • 2
    • 3
  • The French CIDP study group
  1. 1.Centre de Référence Maladies Neuromusculaires Rares Rhône-AlpesCHU de Saint-EtienneSaint-ÉtienneFrance
  2. 2.Université de LyonSaint-ÉtienneFrance
  3. 3.INSERM U1028, Lyon Neuroscience Research CenterLyonFrance
  4. 4.Centre de Référence Maladies Neuromusculaires RaresHôpital de la SalpêtrièreParisFrance
  5. 5.Service de NeurologieHôpital Henri MondorCréteilFrance
  6. 6.Centre de Référence des Maladies Neuromusculaires et de la SLAHôpital de La TimoneMarseilleFrance
  7. 7.Service de NeurologieCHU de PoitiersPoitiersFrance
  8. 8.Centre de Référence des Maladies Neuromusculaires et SLACHU de NiceNiceFrance
  9. 9.Unité Nerf-Muscle, Service de Neurologie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire VaudoisUniversité de LausanneLausanneSwitzerland
  10. 10.Service de NeurologieCHU de StrasbourgStrasbourgFrance
  11. 11.Service de NeurologieHôpital NordSaint-Etienne cedex 02France

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