Journal of Neurology

, Volume 261, Issue 6, pp 1216–1217 | Cite as

A rare case of conjugal amyotrophic lateral sclerosis

  • Enrica Bersano
  • Serena Servo
  • Roberto Cantello
  • Letizia Mazzini
Letter to the Editors

Dear Sirs,

We report a case of conjugal amyotrophic lateral sclerosis (ALS) encountered in our tertiary ALS Centre. Family trees, possible environmental factors, and all known ALS-associated genes have been studied.

The incidence of sporadic ALS ranges from 1.33 to 3.22 per 100,000, and the prevalence in Italy is 5.2 to 8.0 per 100,000 inhabitants [1]. Our patients lived in the Piedmont Region, in Northern Italy, where the incidence is 2.90/100,000 population, and the prevalence is 7.89 to 8.00/100,000 [2].

Since ALS is such a rare disease, chances of conjugal ALS are extremely low, estimated to be about 1 in 510,000 couples. To our knowledge only 20 cases have been reported of both spouses suffering from ALS [3, 4, 5].

In 2005, a 63-year-old man was diagnosed with spinal onset ALS after presenting with a two-year history of widespread fasciculations and progressive gait impairment. On neurological examination we found diffuse spontaneous fasciculations, moderate atrophy and weakness...


Amyotrophic Lateral Sclerosis Transcranial Magnetic Stimulation Cerebral Spinal Fluid Sporadic Amyotrophic Lateral Sclerosis Motor Unit Action Potential 
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Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standards

We declare that we got appropriate informed consent from the patients and respect their confidentiality and anonymity. We declare that our study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Enrica Bersano
    • 1
  • Serena Servo
    • 1
  • Roberto Cantello
    • 1
  • Letizia Mazzini
    • 1
  1. 1.Department of Neurology, ALS CenterEastern Piedmont University, Maggiore della Carità HospitalNovaraItaly

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