Journal of Neurology

, Volume 261, Issue 5, pp 913–924

Clinical, cognitive, and behavioural correlates of white matter damage in progressive supranuclear palsy

  • Federica Agosta
  • Sebastiano Galantucci
  • Marina Svetel
  • Milica Ječmenica Lukić
  • Massimiliano Copetti
  • Kristina Davidovic
  • Aleksandra Tomić
  • Edoardo G. Spinelli
  • Vladimir S. Kostić
  • Massimo Filippi
Original Communication

DOI: 10.1007/s00415-014-7301-3

Cite this article as:
Agosta, F., Galantucci, S., Svetel, M. et al. J Neurol (2014) 261: 913. doi:10.1007/s00415-014-7301-3

Abstract

White matter (WM) tract alterations were assessed in patients with progressive supranuclear palsy (PSP) relative to healthy controls and patients with idiopathic Parkinson’s disease (PD) to explore the relationship of WM tract damage with clinical disease severity, performance on cognitive tests, and apathy. 37 PSP patients, 41 PD patients, and 34 healthy controls underwent an MRI scan and clinical testing to evaluate physical disability, cognitive impairment, and apathy. In PSP, the contribution of WM tract damage to global disease severity and cognitive and behavioural disturbances was assessed using Random Forest analysis. Relative to controls, PSP patients showed diffusion tensor (DT) MRI abnormalities of the corpus callosum, superior cerebellar peduncle (SCP), cingulum and uncinate fasciculus bilaterally, and right inferior longitudinal fasciculus. Corpus callosum and SCP DT MRI measures distinguished PSP from PD patients with high accuracy (area under the curve ranging from 0.89 to 0.72). In PSP, DT MRI metrics of the corpus callosum and superior cerebellar peduncles were the best predictors of global disease severity scale scores. DT MRI metrics of the corpus callosum, right superior longitudinal and inferior longitudinal fasciculus, and left uncinate were the best predictors of executive dysfunction. In PSP, apathy severity was related to the damage to the corpus callosum, right superior longitudinal, and uncinate fasciculi. In conclusion, WM tract damage contributes to the motor, cognitive, and behavioural deficits in PSP. DT MRI offers markers for PSP diagnosis, assessment, and monitoring.

Keywords

Progressive supranuclear palsy White matter tract damage Diffusion tensor MRI Tractography Clinical correlations 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Federica Agosta
    • 1
  • Sebastiano Galantucci
    • 1
  • Marina Svetel
    • 3
  • Milica Ječmenica Lukić
    • 3
  • Massimiliano Copetti
    • 4
  • Kristina Davidovic
    • 3
  • Aleksandra Tomić
    • 3
  • Edoardo G. Spinelli
    • 1
    • 2
  • Vladimir S. Kostić
    • 3
  • Massimo Filippi
    • 1
    • 2
  1. 1.Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly
  2. 2.Department of Neurology, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly
  3. 3.Clinic of Neurology, Faculty of MedicineUniversity of BelgradeBelgradeSerbia
  4. 4.Biostatistics Unit, IRCCS-Ospedale Casa Sollievo della SofferenzaFoggiaItaly

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