Journal of Neurology

, Volume 261, Issue 4, pp 828–830 | Cite as

Etoposide/carboplatin chemotherapy for the treatment of metastatic myxomatous cerebral aneurysms

  • Meret Branscheidt
  • Karl Frontzek
  • Oliver Bozinov
  • Anton Valavanis
  • Elisabeth J. Rushing
  • Michael Weller
  • Susanne Wegener
Letter to the Editors

Dear Sirs,

Myxomas comprise the majority of cardiac tumors [1]. Patients may experience signs of cardiac obstruction or systemic embolism, accompanied by non-specific systemic symptoms such as fever or malaise [2]. Embolization to the central nervous system is common. However, while embolic stroke due to cardiac myxoma is treated by tumor resection, delayed neurological complications may arise from metastatic spread of myxomatous cells into the brain, causing either aneurysms or solid tumor growth. In these rare cases, the clinical course is often complicated and an effective therapeutic regimen has not yet been established (Online Resource 1) [3, 4, 5, 6, 7, 8, 9, 10].

A 41-year-old female patient was referred following a brain magnetic resonance imaging (MRI) scan for the diagnostic work-up of new-onset “burning” headaches and increasing fatigue. MRI showed multiple acute and subacute T2-hyperintensities, suggesting a proximal embolic source or possibly vasculitis (Online Resource...


Body Surface Area Cardiac Myxoma Hematoma Volume Solid Tumor Growth Severe Neurological Impairment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standard

This study has been approved by the appropriate ethics committee and has therefore been performed in the accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Supplementary material

415_2014_7281_MOESM1_ESM.pdf (17 kb)
Supplementary material 1 (PDF 16 kb)
415_2014_7281_MOESM2_ESM.pdf (91 kb)
Supplementary material 2 (PDF 91 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Meret Branscheidt
    • 1
  • Karl Frontzek
    • 2
  • Oliver Bozinov
    • 3
  • Anton Valavanis
    • 4
  • Elisabeth J. Rushing
    • 2
  • Michael Weller
    • 1
  • Susanne Wegener
    • 1
  1. 1.Department of NeurologyUniversity Hospital ZurichZurichSwitzerland
  2. 2.Department of NeuropathologyUniversity Hospital ZurichZurichSwitzerland
  3. 3.Department of NeurosurgeryUniversity Hospital ZurichZurichSwitzerland
  4. 4.Department of NeuroradiologyUniversity Hospital ZurichZurichSwitzerland

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