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Journal of Neurology

, Volume 260, Issue 7, pp 1748–1751 | Cite as

Obstructive sleep apnea in idiopathic intracranial hypertension: comparison with matched population data

  • Matthew J. Thurtell
  • Lynn Marie Trotti
  • Edward O. Bixler
  • David B. Rye
  • Donald L. Bliwise
  • Nancy J. Newman
  • Valérie Biousse
  • Beau B. Bruce
Original Communication

Abstract

Patients with idiopathic intracranial hypertension (IIH) frequently have coexisting obstructive sleep apnea (OSA). We aimed to determine if the prevalence and severity of OSA is greater in patients with IIH than would be expected, given their other risk factors for OSA. We included 24 patients (20 women, four men) with newly-diagnosed IIH who had undergone overnight polysomnography. We calculated the expected apnea-hypopnea index (AHI) for each patient, based on their age, sex, race, body mass index (BMI), and menopausal status, using a model derived from 1,741 randomly-sampled members of the general population who had undergone overnight polysomnography. We compared the AHI values obtained from polysomnography with those predicted by the model using a paired t test. Our study had 80 % power to detect a 10-unit change in mean AHI at α = 0.05. Eight patients (33.3 %; six women, two men) had OSA by polysomnography. AHIs from polysomnography were not significantly different from those predicted by the model (mean difference 3.5, 95 % CI: −3.0−9.9, p = 0.28). We conclude that the prevalence and severity of OSA in IIH patients is no greater than would be expected for their age, sex, race, BMI, and menopausal status. It remains unclear whether the presence or treatment of OSA influences the clinical course of IIH.

Keywords

Idiopathic intracranial hypertension Papilledema Obstructive sleep apnea Intracranial pressure 

Notes

Acknowledgments

NIH/NEI core grant P30-EY06360 (Department of Ophthalmology); Research to Prevent Blindness Lew R. Wasserman Merit Award (NJN); Department of Ophthalmology grant (MJT, BBB) from Research to Prevent Blindness Inc, New York, NY. In addition, Dr. Bruce receives research support from the NIH/NEI (K23-EY019341).

Conflicts of interest

Dr. Thurtell reports no conflicts of interest. Dr. Trotti reports no conflicts of interest. Dr. Bixler reports no conflicts of interest. Dr. Rye reports no conflicts of interest. Dr. Bliwise reports no conflicts of interest. Dr. Newman reports no conflicts of interest. Dr. Biousse reports no conflicts of interest. Dr. Bruce reports no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Matthew J. Thurtell
    • 1
    • 6
    • 7
    • 8
    • 9
  • Lynn Marie Trotti
    • 2
  • Edward O. Bixler
    • 10
  • David B. Rye
    • 2
  • Donald L. Bliwise
    • 2
  • Nancy J. Newman
    • 1
    • 2
    • 3
  • Valérie Biousse
    • 1
    • 2
  • Beau B. Bruce
    • 1
    • 2
    • 4
    • 5
  1. 1.Department of OphthalmologyEmory UniversityAtlantaUSA
  2. 2.Department of NeurologyEmory UniversityAtlantaUSA
  3. 3.Department of Neurological SurgeryEmory UniversityAtlantaUSA
  4. 4.Rollins School of Public HealthEmory UniversityAtlantaUSA
  5. 5.Laney Graduate SchoolEmory UniversityAtlantaUSA
  6. 6.Department of Ophthalmology and Visual SciencesUniversity of IowaIowa CityUSA
  7. 7.Department of NeurologyUniversity of IowaIowa CityUSA
  8. 8.Neurology ServiceVeterans Affairs Medical CenterIowa CityUSA
  9. 9.Center for the Prevention and Treatment of Visual LossVeterans Affairs Medical CenterIowa CityUSA
  10. 10.Department of PsychiatryPennsylvania State University College of MedicineHersheyUSA

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