Lithium neurotoxicity mimicking rapidly progressive dementia
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Lithium is currently used in the prophylaxis and treatment of depression and bipolar disorders. It is rapidly assimilated by gastrointestinal tract and mainly eliminated by the kidney. The narrow therapeutic range and the well-known adverse effects represent two important limits to its utilization in clinical practice: serum levels of lithium should be assessed every 3–6 months, since intoxication may determine renal failure, thyroid dysfunction, cardiac arrhythmias and neurotoxicity including tremor, nystagmus, ataxia, seizures and even coma . Here we describe a case of insidious-onset lithium intoxication resembling a progressive neurodegenerative dementia and requiring differential diagnosis with Creutzfeldt-Jacob disease (CJD).
KeywordsLithium Bipolar Disorder Olanzapine Sodium Valproate Progressive Dementia
Conflicts of interest
This study has been approved by the appropriate ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.
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