Journal of Neurology

, Volume 260, Issue 7, pp 1709–1713

Imaging resting state brain function in multiple sclerosis

  • Massimo Filippi
  • Federica Agosta
  • Edoardo G. Spinelli
  • Maria Assunta Rocca
Review

Abstract

In multiple sclerosis (MS), physical and cognitive deficits not only reflect structural damage, but also functional imbalance in and between brain networks. Resting-state functional magnetic resonance imaging (fMRI) allows one to investigate intrinsic, synchronized brain activity across the whole brain, and to measure the degree of functional correlation between different cortical regions. This review describes the major findings obtained in MS patients at different clinical stages using resting state fMRI, and discusses how the use of fMRI techniques may improve our ability to identify novel biomarkers useful in the context of the diagnostic work-up, establishing prognosis and monitoring treatment.

Keywords

Multiple sclerosis Functional MRI Resting-state Functional reorganization Default-mode network Cognitive impairment 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Massimo Filippi
    • 1
  • Federica Agosta
    • 1
  • Edoardo G. Spinelli
    • 1
  • Maria Assunta Rocca
    • 1
  1. 1.Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly

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