Journal of Neurology

, Volume 260, Issue 2, pp 429–437 | Cite as

Clinical characteristics of impulse control and repetitive behavior disorders in Parkinson’s disease

  • Juyeon Kim
  • Mijin Kim
  • Do Young Kwon
  • Woo-Keun Seo
  • Ji Hyun Kim
  • Jong Sam Baik
  • Seong-Beom Koh
Original Communication

Abstract

Impulse control and repetitive behavior disorders (ICRBs) are a group of diseases including impulse control disorder (ICD), repetitive behavior disorder (RB), and dopamine dysregulation syndrome (DDS). This study determined the prevalence and associated characteristics of ICRBs in Parkinson’s disease (PD) patients. Included were 297 patients, interviewed with the questionnaire for impulsive-compulsive disorders in PD for screening of various ICRBs. Questionnaire results and clinical characteristics were analyzed. The ICRB prevalence among PD patients was 15.5 % (46 of 297), with 35 patients with ICD, 20 with RB, and 7 with DDS. Patients with ICRB were predominantly male, younger, taking higher doses of dopaminergic drugs, and had longer disease duration, worse Unified Parkinson’s Disease Rating Scale (UPDRS) motor score, and worse PD quality of life questionnaire score. However, each ICRB subtype had different risk factor profiles. ICD patients were predominantly male, younger, had longer disease duration, were affected by PD from young age, were taking higher total dopaminergic drug dosages, and had more RB. RB patients had higher UPDRS part III scores, were taking higher levodopa doses, and had higher comorbid ICD. DDS patients were taking higher dopamine agonist doses, and had more frequent ICD. In multivariate logistic regression for secondary analysis, only younger age and comorbid RB or DDS showed significant association with ICD and only poor UPDRS III score and comorbid ICD were significantly associated with RB. These findings suggested that different risk factors contribute to development of each ICRB subtype. ICRB could be a combination of heterogeneous disease entities that need to be treated separately.

Keywords

Parkinson’s disease Impulse control disorder Repetitive behavior disorder Dopamine dysregulation syndrome 

Notes

Acknowledgments

We are grateful to Professor Daniel Weintraub for his permission of using the QUIP in this research. This study was supported by the basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010-0027994).

Conflicts of interest

None.

Ethical standard

This study has been approved by the appropriate ethics committee and has, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Juyeon Kim
    • 1
  • Mijin Kim
    • 1
  • Do Young Kwon
    • 1
  • Woo-Keun Seo
    • 1
  • Ji Hyun Kim
    • 1
  • Jong Sam Baik
    • 2
  • Seong-Beom Koh
    • 1
  1. 1.Department of NeurologyGuro Hospital, Korea University College of MedicineSeoulRepublic of Korea
  2. 2.Department of NeurologySanggye Paik Hospital, Inje University College of MedicineSeoulRepublic of Korea

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