Journal of Neurology

, Volume 260, Issue 3, pp 701–713 | Cite as

Botulinum toxin therapy: its use for neurological disorders of the autonomic nervous system

  • Dirk DresslerEmail author


Botulinum toxin (BoNT) has gained widespread use for the treatment of overactive muscles, overactive exocrine glands and, most recently, non-muscular pain conditions. Autonomic conditions treated with BoNT include achalasia, gastroparesis, sphincter of Oddi spasms, and unspecific esophageal spasms in gastroenterology and prostate disorders in urology. BoNT’s use for autonomic conditions related to neurology includes various forms of bladder dysfunction (detrusor sphincter dyssynergia, idiopathic detrusor overactivity, neurogenic detrusor overactivity, urinary retention and bladder pain syndrome), pelvic floor disorders (pelvic floor spasms and anal fissures), hyperhidrosis (axillary, palmar, and plantar hyperhidrosis, diffuse sweating, Frey’s syndrome) and hypersalivation (hypersalivation in Parkinsonian syndromes, motor neuron disease, neuroleptic use, and cerebral palsy). Hyperhidrosis, hypersalivation, some forms of bladder dysfunction and pelvic floor disorders can easily be treated by neurologists. Most bladder dysfunctions require cooperation with urology departments.


Botulinum toxin Therapeutic use Autonomic disorders Neurology 


Conflicts of interest

DD receives compensation for consultancy work for Allergan, Ipsen, Eisai/Solstice and Merz. He is shareholder of Allergan.


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© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Movement Disorders Section, Department of NeurologyHannover Medical SchoolHannoverGermany

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