Journal of Neurology

, Volume 259, Issue 9, pp 1976–1978 | Cite as

Clinical and radiological response of leptomeningeal melanoma after whole brain radiotherapy and ipilimumab

Letter to the Editors

References

  1. 1.
    Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711–723PubMedCrossRefGoogle Scholar
  2. 2.
    Hodi FS, Oble DA, Drappatz J, Velazquez EF, Ramaiya N, Ramakrishna N et al (2008) CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS. Nat Clin Pract Oncol 5(9):557–561 (7)Google Scholar
  3. 3.
    Schartz NEC, Farges C, Madelaine I, Bruzzoni H, Calvo F, Hoos A et al (2010) Complete regression of a previously untreated melanoma brain metastasis with ipilimumab. Melanoma Res 20:247–250PubMedGoogle Scholar
  4. 4.
    Landelijke Werkgroep Neuro-oncologie (LWNO) (2006, revision 2010) Landelijke richtlijn Diagnostiek en behandeling van leptomeningeale metastasen van solide tumorenGoogle Scholar
  5. 5.
    Boogerd W, Du Bois WFJ, Teepenen JLJM, Rosenbrand CJGM (2007) Richlijn ‘Leptomeningeale metastasen van solide tumoren’. Ned Tijdschr Geneesk 151:123–128Google Scholar
  6. 6.
    Freilich RJ, Krol G, DeAngelis LM (1995) Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis. Ann Neurol 38(1):51–57PubMedCrossRefGoogle Scholar
  7. 7.
    Straathof CS, de Bruin HG, Dippel DW, Vecht CJ (1999) The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis. J Neurol 246(9):810–814PubMedCrossRefGoogle Scholar
  8. 8.
    Collie DA, Brush JP, Lammie GA, Grant R, Kunkler I, Leonard R et al (1999) Imaging features of leptomeningeal metastases. Clin Radiol 54(11):765–771PubMedCrossRefGoogle Scholar
  9. 9.
    National Comprehensive Cancer Network (NCCN) (2012) NCCN Guidelines Version 1.2012 Leptomeningeal metastasesGoogle Scholar
  10. 10.
    Harstad L, Hess KR, Groves MD (2008) Prognostic factors and outcomes in patients with leptomeningeal melanomatosis. Neuro Oncol 10(6):1010–1018PubMedCrossRefGoogle Scholar
  11. 11.
    Dewan MZ, Galloway AE, Kawashima N, Dewyngaert JK, Babb JS, Formenti SC et al (2009) Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 15:5379–5388PubMedCrossRefGoogle Scholar
  12. 12.
    Lugade AA, Moran JP, Gerber SA, Rose RC, Frelinger JG, Lord EM (2005) Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J Immunol 174:7516–7523PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Neuro-oncology, Antoni van Leeuwenhoek HospitalNetherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Department of Medical Oncology, Antoni van Leeuwenhoek HospitalNetherlands Cancer InstituteAmsterdamThe Netherlands
  3. 3.Department of NeurologyUniversity Medical Centre Nijmegen St RadboudNijmegenThe Netherlands

Personalised recommendations