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Journal of Neurology

, Volume 259, Issue 8, pp 1742–1745 | Cite as

Hyperintense lesion in the corpus callosum associated with Puumala hantavirus infection

  • Thorsten Steiner
  • Jakob Ettinger
  • Zhongying Peng
  • Jörg Hofmann
  • Marius Hartmann
  • Ulrich Burkhardt
  • Paul SchnitzlerEmail author
Letter to the Editors

Dear Sir,

A 38-year-old female presented with a 4-day history of acute onset of headache, fever of 40°C, and generalized fatigue at a peripheral hospital. The patient presented no neurological deficits, especially no signs of meningism, and the remaining examination was normal. The CRP was increased (192 mg/l, normal <5 mg/l). Creatinine (1.03 mg/dl) and blood urea nitrogen (38.0 mg/dl) were normal. The cranial CT scanning excluded subarachnoid hemorrhage. A cranial MRI excluded cerebral venous sinus thrombosis, but showed a hyperintense lesion in the splenium of the corpus callosum (Fig.  1a–c). The patient was transferred to the university hospital. A lumbar puncture could not be performed at that time, due to thrombocytopenia and abnormal coagulation (platelets 51 × 10 3/μl and the partial thromboplastin (PTT) time was prolonged to 44.1 s). The general condition of health was reduced, accompanied by tachycardia and dyspnea, but vigilance was not affected and neurological examination...

Keywords

Corpus Callosum Rabies Bank Vole Cerebral Venous Sinus Thrombosis Nipah Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Expert technical assistance by Mrs. C. Stephan (Charité Berlin) is gratefully acknowledged.

Conflicts of interest

None.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Thorsten Steiner
    • 1
  • Jakob Ettinger
    • 3
  • Zhongying Peng
    • 2
  • Jörg Hofmann
    • 3
  • Marius Hartmann
    • 4
  • Ulrich Burkhardt
    • 5
  • Paul Schnitzler
    • 5
    Email author
  1. 1.Department of NeurologyKlinikum Frankfurt HöchstFrankfurtGermany
  2. 2.Department of NeurologyUniversity of HeidelbergHeidelbergGermany
  3. 3.Institute of Medical Virology, Helmut-Ruska-HausCharité University MedicineBerlinGermany
  4. 4.Department of NeuroradiologyHelios Klinikum Berlin-BuchBerlinGermany
  5. 5.Department of Infectious Diseases, VirologyUniversity of HeidelbergHeidelbergGermany

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