No evidence for an association between genetic variation at the MMP2 and MMP9 loci and aneurysmal subarachnoid haemorrhage
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Subarachnoid haemorrhage (SAH) is a serious condition that has a young age onset and poor outcome . Approximately 75% of the cases of SAH are due to the rupture of an intracranial aneurysm (IA) . The most important risk factors are smoking, hypertension, and excessive alcohol intake . In addition, genetic factors have been shown to play an important role .
The matrix metalloproteinases (MMP) can degrade extracellular matrix (ECM) components, and alteration of the ECM leads to changes of the vessel wall. There is evidence that matrix remodelling plays a role in the formation and rupture of IA. MMP9 levels has been found to be increased in the aneurysmal wall , and both MMP2 and MMP9 was found to be overexpressed in cerebral ruptured aneurysms compared with unruptured aneurysms .
To evaluate the role of genetic variants in MMP2 and MMP9 in SAH due to ruptured IA (aSAH), the genes were tagged using HapMap CEU data (Rel 23a) and Haploview (r2 = 0.8 and...
KeywordsSubarachnoid Haemorrhage Haplotype Analysis Intracranial Aneurysm Aneurysmal Subarachnoid Haemorrhage Analyse Genetic Variant
This study was supported by the Swedish Research Council (K2011-65X-14605-09-6), the Swedish state (ALFGBG-148861), the Swedish Heart and Lung Foundation (20100256), as well as the Rune and Ulla Amlöv, Edit Jacobson, John and Brit Wennerström, Lars Hierta O.E. and Edla Johansson, Tore Nilsson, and Emelle Foundations.
Conflict of interest
The authors declare that they have no conflict of interest.
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