Journal of Neurology

, Volume 258, Issue 11, pp 2054–2057 | Cite as

Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea

  • Hui-Chun Huang
  • Yu-Chin Wu
  • Lee-Yung Shih
  • Woei-Chung Lo
  • Chon-Haw Tsai
  • Woei-Cherng Shyu
Original Communication


We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) and 99mTc-labeled tropane dopamine transporter (99mTc-TRODAT-1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and 99mTc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.


Chorea Polycythemia vera PET 99mTc-TRODAT-1 



The study was supported by grants from the Department of Health, Executive Yuan, Taiwan (DOH99-TD-C-111-006), the China Medical University Hospital (DMR-99-190), and the National Science Council (NSC 99-2314-B-039-016-MY2). This study was also supported in part by the Taiwan Department of Health Clinical Trial and Research Centre of Excellence (DOH100-TD-B-111-004).

Conflict of interest



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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of NeurologyChina Medical University HospitalTaichungTaiwan
  2. 2.Department of Nuclear Medicine and PET CenterChina Medical University HospitalTaichungTaiwan
  3. 3.Division of Hematology-OncologyChang Gung Memorial HospitalTaipeiTaiwan
  4. 4.School of MedicineChang Gung UniversityTaipeiTaiwan
  5. 5.Department of Oncology and HematologyChina Medical University HospitalTaichungTaiwan
  6. 6.School of MedicineChina Medical UniversityTaichungTaiwan
  7. 7.Graduate Institute of Neural and Cognitive SciencesChina Medical UniversityTaichungTaiwan
  8. 8.Graduate Institute of ImmunologyChina Medical UniversityTaichungTaiwan

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