Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea
- 198 Downloads
We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) and 99mTc-labeled tropane dopamine transporter (99mTc-TRODAT-1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and 99mTc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.
KeywordsChorea Polycythemia vera PET 99mTc-TRODAT-1
The study was supported by grants from the Department of Health, Executive Yuan, Taiwan (DOH99-TD-C-111-006), the China Medical University Hospital (DMR-99-190), and the National Science Council (NSC 99-2314-B-039-016-MY2). This study was also supported in part by the Taiwan Department of Health Clinical Trial and Research Centre of Excellence (DOH100-TD-B-111-004).
Conflict of interest
- 16.Swerdlow SH, Campo E, Harris NL et al (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC Press, LyonGoogle Scholar