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Journal of Neurology

, Volume 258, Issue 11, pp 1949–1957 | Cite as

White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study

  • Shigenori Kanno
  • Nobuhito Abe
  • Makoto Saito
  • Masahito Takagi
  • Yoshiyuki Nishio
  • Akiko Hayashi
  • Makoto Uchiyama
  • Risa Hanaki
  • Hirokazu Kikuchi
  • Kotaro Hiraoka
  • Hiroshi Yamasaki
  • Osamu Iizuka
  • Atsushi Takeda
  • Yasuto Itoyama
  • Shoki Takahashi
  • Etsuro Mori
Original Communication

Abstract

The aim of this study was to characterise the white matter damage involved in idiopathic normal pressure hydrocephalus (INPH) using diffusion tensor imaging (DTI) and the relationship between this damage and clinical presentation. Twenty patients with INPH, 20 patients with Alzheimer’s disease and 20 patients with idiopathic Parkinson’s disease (as disease control groups) were enrolled in this study. Mean diffusivity (MD) and fractional anisotropy (FA) were determined using DTI, and these measures were analysed to compare the INPH group with the control groups and with certain clinical correlates. On average, the supratentorial white matter presented higher MD and lower FA in the INPH group than in the control groups. In the INPH group, the mean hemispheric FA correlated with some of the clinical measures, whereas the mean hemispheric MD did not. On a voxel-based statistical map, white matter involvement with high MD was localised to the periventricular regions, and white matter involvement with low FA was localised to the corpus callosum and the subcortical regions. The total scores on the Frontal Assessment Battery were correlated with the FA in the frontal and parietal subcortical white matter, and an index of gait disturbance was correlated with the FA in the anterior limb of the left internal capsule and under the left supplementary motor area. DTI revealed the presence of white matter involvement in INPH. Whereas white matter regions with high MD were not related to symptom manifestation, those with low FA were related to motor and cognitive dysfunction in INPH.

Keywords

Idiopathic normal pressure hydrocephalus Diffusion tensor imaging White matter Alzheimer’s disease Parkinson’s disease 

Notes

Acknowledgments

We thank the patients and their families for their participation in this study. We also thank Takeo Kondo and Kazutomo Nishijima for their constant support. This study was supported by a Grant-in-Aid for Scientific Research on Priority Areas—System study on higher-order brain functions from the MECSST Japan (20020004) and by the Ministry of Health, Labor and Welfare of Japan.

Conflict of interest

None.

Supplementary material

415_2011_6038_MOESM1_ESM.doc (34 kb)
Supplementary material 1 (DOC 34 kb)
415_2011_6038_MOESM2_ESM.doc (31 kb)
Supplementary material 2 (DOC 31 kb)

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Shigenori Kanno
    • 1
  • Nobuhito Abe
    • 1
  • Makoto Saito
    • 1
  • Masahito Takagi
    • 1
  • Yoshiyuki Nishio
    • 1
  • Akiko Hayashi
    • 1
  • Makoto Uchiyama
    • 1
  • Risa Hanaki
    • 1
  • Hirokazu Kikuchi
    • 1
  • Kotaro Hiraoka
    • 1
  • Hiroshi Yamasaki
    • 1
  • Osamu Iizuka
    • 1
  • Atsushi Takeda
    • 2
  • Yasuto Itoyama
    • 2
  • Shoki Takahashi
    • 3
  • Etsuro Mori
    • 1
  1. 1.Department of Behavioral Neurology and Cognitive NeuroscienceTohoku University Graduate School of MedicineSendaiJapan
  2. 2.Department of NeurologyTohoku University Graduate School of MedicineSendaiJapan
  3. 3.Department of Diagnostic RadiologyTohoku University Graduate School of MedicineSendaiJapan

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