No evidence for an association between genetic variation at the SERPINI1 locus and ischemic stroke
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Neuroserpin, primarily expressed by neurons, is an important inhibitor of tissue-type plasminogen activator (t-PA). t-PA has a multifaceted role in the brain and is involved in several physiologic and pathologic processes. Its beneficial role on the vascular side is attributed to its thrombolytic function. Moreover, recombinant t-PA is the only FDA-approved pharmacological treatment of acute ischemic stroke (IS) . In the brain there are several cell-types that express t-PA besides the cerebrovascular endothelial cells, e.g. neurons, microglia and astrocytes . Under physiological conditions t-PA is involved in synaptic plasticity and memory-related processes [3, 4]. However, during pathological conditions, such as in the acute phase of IS, excess release of t-PA may trigger proteolytic cascades, subsequently leading to excitotoxicity and neurodegeneration [5, 6]. In this context, t-PA has been associated with increased stroke volume  and increased cerebrovascular...
KeywordsIschemic Stroke Minor Allele Frequency Increase Stroke Volume Brain Barrier Permeability Reduce Infarct Volume
The present study was supported by the Swedish Research Council (K2011-65X-14605-09-6), the Swedish state (ALFBGB-148861), the Swedish Heart and Lung Foundation (20100256), the Yngve Land Foundation for Neurological Research, the Göteborg Foundation for Neurological Research, the Swedish Brain Foundation, and the John and Brit Wennerström, Rune and Ulla Amlöv, Edit Jacobson, Per-Olof Ahl, Tore Nilsson, and Emelle Foundations. Genotyping was performed by the SNP&SEQ Technology Platform in Uppsala, which is supported by Uppsala University, Uppsala University Hospital, Science for Life Laboratory - Uppsala and the Swedish Research Council (Contracts 80576801 and 70374401).
Conflict of interest
The authors declare that they have no conflict of interest.
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