Localisation of the applause sign in a patient with acute bilateral lenticular infarction
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The ‘applause sign’ refers to a tendency to initiate an automatic series of hand-claps despite instruction to clap three times only . It is not specific for any one condition, but has been associated with progressive supranuclear palsy (PSP) in particular  and has also been described in corticobasal degeneration, multiple system atrophy and idiopathic Parkinson’s disease . Localisation of the pathology that gives rise to the applause sign is uncertain. A combination of frontal cortical and basal ganglia dysfunction has been suggested. There has been one previous report of the applause sign in a patient without a known neurodegenerative disease. This occurred in a patient with diffuse B-cell lymphoma involving the putamen on one side; however, there was also extensive subcortical white matter disease bilaterally .
A 70-year-old man presented with sudden onset left hemiparesis. He was a diabetic with hypertension and hyperlipidemia. His family reported that he was...
KeywordsMultiple System Atrophy Progressive Supranuclear Palsy Globus Pallidus Progressive Supranuclear Palsy Lentiform Nucleus
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