Long-term efficiency of intravenously administered immunoglobulin in anti-Yo syndrome with paraneoplastic cerebellar degeneration
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Paraneoplastic cerebellar degeneration (PCD) is a rare heterogeneous group of disorders associated with cancer and anti-neuronal antibodies. Patients display symptoms reflecting cerebellar dysfunction including dysarthria, severe ataxia and abnormal oculomotor functions. Anti-Yo antibodies, also often called Purkinje cell antibodies type 1 (PCA-1), occur in patients with PCD having a history of tumors of the ovary, endometrium, fallopian tube or breast cancer [6, 11]. The treatment of PCD associated with anti-Yo antibodies is very limited and does usually not respond to immunosuppressive or tumor therapy. We report improvement and stabilization in a patient with an anti-Yo syndrome with PCD secondary to ovarian carcinoma through 10 years of treatment with intravenous immunoglobuline (IVIG).
KeywordsPurkinje Cell Ovarian Carcinoma Cerebellar Ataxia IVIG Treatment Spontaneous Nystagmus
We would like to thank the patient reported here for her participation and encouragement. J.S., P.R., P.S., M.C.W. and B.S. are members of the German network on muscular dystrophies (MD-NET) funded by the German Ministry of Education and Research (BMBF, Bonn, Germany).
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