Journal of Neurology

, Volume 258, Issue 4, pp 533–548 | Cite as

The role of cytokines in Guillain–Barré syndrome



Cytokines play an important role in the pathogenesis of autoimmune diseases including Guillain–Barré syndrome (GBS) and its animal model experimental autoimmune neuritis (EAN). In this article, we reviewed the current knowledge of the role of cytokines such as TNF-α, IFN-γ, IL-1β, IL-6, IL-12, IL-18, IL-23, IL-17, IL-10, IL-4 and chemokines in GBS and EAN as unraveled by studies both in the clinic and the laboratory. However, these studies occasionally yield conflicting results, highlighting the complex role that cytokines play in the disease process. Efforts to modulate cytokine function in GBS and other autoimmune disease have shown efficiency indicating that cytokines are important therapeutic targets.


Cytokine Guillain–Barré syndrome Experimental autoimmune neuritis Autoimmunity T cell 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Neurology, The First HospitalJilin UniversityChangchunChina
  2. 2.Department of Neurology, The First HospitalDalian Medical UniversityDalianChina
  3. 3.Division of Neurodegeneration (NOVUM, plan 5), Department of Neurobiology, Care Sciences and Society, Karolinska InstituteKarolinska University Hospital in HuddingeStockholmSweden

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