Journal of Neurology

, Volume 257, Issue 12, pp 2099–2100 | Cite as

Severe encephalopathy and polyneuropathy induced by dichloroacetate

  • Dieta Brandsma
  • Thomas P. C. Dorlo
  • Haanen John H. 
  • Jos H. Beijnen
  • Willem Boogerd
Letter to the Editors

References

  1. 1.
    Coglan A (2007) Cheap, ‘safe’ drug kills most cancers. New Scientist magazine 11Google Scholar
  2. 2.
    Bonnet S, Archer SL, Allalunis-Turner J et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11:37–51CrossRefPubMedGoogle Scholar
  3. 3.
    Michelakis ED, Webster L, Mackey JR (2008) Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 99:989–994CrossRefPubMedGoogle Scholar
  4. 4.
    Michelakis ED, Sutendra G, Dromparis P et al (2010) Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med 2(31):31–34Google Scholar
  5. 5.
    Stacpoole PW, Kerr DS, Barnes C et al (2006) Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 117:1519–1531CrossRefPubMedGoogle Scholar
  6. 6.
    Kaufmann P, Engelstad K, Wei Y et al (2006) Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology 66:324–330CrossRefPubMedGoogle Scholar
  7. 7.
    Shroads AL, Guo X, Dixit V, Liu HP, James MO, Stacpoole PW (2008) Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity. J Pharmacol Exp Ther 324:1163–1171CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Dieta Brandsma
    • 1
    • 2
  • Thomas P. C. Dorlo
    • 3
  • Haanen John H. 
    • 4
  • Jos H. Beijnen
    • 3
  • Willem Boogerd
    • 1
    • 2
  1. 1.Department of Neuro-oncologyAntoni van Leeuwenhoek Hospital/The Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Department of NeurologySlotervaart HospitalAmsterdamThe Netherlands
  3. 3.Department of Pharmacy & PharmacologySlotervaart Hospital/The Netherlands Cancer InstituteAmsterdamThe Netherlands
  4. 4.Department of Medical OncologyAntoni van Leeuwenhoek Hospital/The Netherlands Cancer InstituteAmsterdamThe Netherlands

Personalised recommendations