Journal of Neurology

, Volume 257, Issue 7, pp 1092–1098

An fMRI study of musicians with focal dystonia during tapping tasks

  • Hiroshi Kadota
  • Yasoichi Nakajima
  • Makoto Miyazaki
  • Hirofumi Sekiguchi
  • Yutaka Kohno
  • Masatoshi Amako
  • Hiroshi Arino
  • Koichi Nemoto
  • Naotaka Sakai
Original Communication

Abstract

Musician’s dystonia is a type of task specific dystonia for which the pathophysiology is not clear. In this study, we performed functional magnetic resonance imaging to investigate the motor-related brain activity associated with musician’s dystonia. We compared brain activities measured from subjects with focal hand dystonia and normal (control) musicians during right-hand, left-hand, and both-hands tapping tasks. We found activations in the thalamus and the basal ganglia during the tapping tasks in the control group but not in the dystonia group. For both groups, we detected significant activations in the contralateral sensorimotor areas, including the premotor area and cerebellum, during each tapping task. Moreover, direct comparison between the dystonia and control groups showed that the dystonia group had greater activity in the ipsilateral premotor area during the right-hand tapping task and less activity in the left cerebellum during the both-hands tapping task. Thus, the dystonic musicians showed irregular activation patterns in the motor-association system. We suggest that irregular neural activity patterns in dystonic subjects reflect dystonic neural malfunction and consequent compensatory activity to maintain appropriate voluntary movements.

Keywords

Functional magnetic resonance imaging Musician Dystonia Premotor cortex 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Hiroshi Kadota
    • 1
    • 2
    • 3
  • Yasoichi Nakajima
    • 1
  • Makoto Miyazaki
    • 1
    • 4
  • Hirofumi Sekiguchi
    • 1
    • 5
  • Yutaka Kohno
    • 1
    • 6
  • Masatoshi Amako
    • 7
  • Hiroshi Arino
    • 7
  • Koichi Nemoto
    • 7
    • 8
  • Naotaka Sakai
    • 9
    • 10
  1. 1.Department of Rehabilitation for Sensory Functions, Research InstituteNational Rehabilitation Center for Persons with DisabilitiesTokorozawaJapan
  2. 2.Course of Functional Control Systems, Graduate School of EngineeringShibaura Institute of TechnologySaitamaJapan
  3. 3.Department of Physical and Health Education, Graduate School of EducationThe University of TokyoTokyoJapan
  4. 4.Research InstituteKochi University of TechnologyKochiJapan
  5. 5.Faculty of Business and Information SciencesJobu UniversityIsesakiJapan
  6. 6.Ibaraki Prefectural University of Health SciencesInashikiJapan
  7. 7.Department of Orthopaedic SurgeryNational Defense Medical CollegeTokorozawaJapan
  8. 8.National Defense Medical College Research Institute, National Defense Medical College3-2 Namiki, TokorozawaSaitamaJapan
  9. 9.Department of Mechanical and Intelligent Engineering, Graduate School of EngineeringUtsunomiya UniversityUtsunomiyaJapan
  10. 10.Department of Orthopedic Surgery, School of MedicineYokohama City UniversityYokohamaJapan

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