Levodopa responsive hemidystonia associated with contralateral nigral lesion
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A focal brain lesion in the basal ganglia or thalamus is frequently the cause of symptomatic hemidystonia. However, brainstem lesions may also induce dystonia with or without parkinsonism [3, 10]. Patients with such secondary dystonia respond poorly to medical treatment [1, 5]. We report a patient who had a 56-years history of levodopa responsive hemidystonia associated with a lesion in the contralateral substantia nigra.
A 63 year-old woman presented with 56 years’ history of dystonia involving the neck and the right arm and leg. Her birth and perinatal histories were unremarkable. At the age of three, she developed a severe febrile illness that was accompanied by mental change for several days. During that insult, she developed right hemiplegia, but improved over a period of 3 months. At the age of seven, she developed dystonia of the right hand and leg. The dystonia was stable until the age of 33, when she first sought medical treatment. She was treated with...
KeywordsLevodopa Dystonia Substantia Nigra Levodopa Treatment Dopa Responsive Dystonia
This work was supported by a faculty research grant of Yonsei University College of Medicine (grant number 6-2008-0236).
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