Journal of Neurology

, Volume 257, Issue 6, pp 999–1003 | Cite as

Is atrial fibrillation associated with poor outcome after thrombolysis?

  • Daniel Šaňák
  • Roman Herzig
  • Michal Král
  • Andrea Bártková
  • Jana Zapletalová
  • Martin Hutyra
  • David Školoudík
  • Ivanka Vlachová
  • Tomáš Veverka
  • David Horák
  • Petr Kaňovský
Original Communication


Atrial fibrillation (AF) is considered a predictor for severe stroke and poor outcome. The aim was to evaluate whether AF is associated with poor outcome in acute ischemic stroke (IS) patients treated with intravenous thrombolysis (IVT). In a retrospective study, 157 consecutive IS patients (98 males, mean age 67.3 ± 10.2 years), treated with IVT within 3 hours from stroke onset, were divided into two groups according to presence/absence of AF. Neurological deficit was evaluated using the NIHSS on admission, 24 hours, and 7 days later, while the 90-day clinical outcome was assessed using the modified Rankin Scale (mRS). A total of 66 patients (38 males) presented with AF. The baseline NIHSS was 13.3 ± 5.4 in AF and 11.0 ± 5.1 points in non-AF patients (P = 0.006). AF patients had arterial occlusions more frequently in the baseline MRA (54.5% in AF versus 25.3% in non-AF, P = 0.0002). No differences were found between groups in clinical improvement after 24 hours and 7 days or in rate of achieved recanalizations. AF patients had significantly poorer 90-day clinical outcome than non-AF patients (median mRS 2.5 vs. 1.0). Patients with AF had significantly worse 90-day clinical outcome after IVT compared to those without AF, probably due to more severe baseline neurological deficits and the greater number of arterial occlusions in the MRA before IVT.


Ischemic stroke Atrial fibrillation Intravenous thrombolysis MRI Clinical outcome 



The study was supported in part by the IGA Ministry of Health, the Czech Republic, grant number NR/8579-3/2005 and by a grant project of the Ministry of Education, the Czech Republic, number MSM 6198959216.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Daniel Šaňák
    • 1
  • Roman Herzig
    • 1
  • Michal Král
    • 1
  • Andrea Bártková
    • 1
  • Jana Zapletalová
    • 2
  • Martin Hutyra
    • 3
  • David Školoudík
    • 1
  • Ivanka Vlachová
    • 1
  • Tomáš Veverka
    • 1
  • David Horák
    • 4
  • Petr Kaňovský
    • 1
  1. 1.Stroke Center, Department of NeurologyPalacký University Medical School and University HospitalOlomoucCzech Republic
  2. 2.Department of Biometry and StatisticsPalacký University Medical SchoolOlomoucCzech Republic
  3. 3.Department of CardiologyPalacký University Medical School and University HospitalOlomoucCzech Republic
  4. 4.Department of RadiologyPalacký University Medical School and University HospitalOlomoucCzech Republic

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