Social and clinical determinants of quality of life in Parkinson’s disease in Austria: a cohort study
- 403 Downloads
Parkinson’s disease (PD) is associated with a reduction of health-related quality of life (HrQoL). Demographic and clinical determinants of HrQoL in PD have been previously investigated, but less is known about its social determinants. Data on HrQoL in Austrian patients with PD are not available. The objective of this cross-sectional survey was to evaluate HrQoL of Austrian patients with PD and to provide a comprehensive analysis of its social and clinical determinants. Outpatients (n = 100) with idiopathic PD were recruited in the Department of Neurology of the University Innsbruck. Clinical status was estimated using the Unified Parkison’s Disease Rating Scale (UPDRS). HrQoL was evaluated using a generic instrument, the EuroQol (EQ5D and EQ-VAS). Independent determinants of HrQoL were assessed in multivariate regression analysis. The proportion of PD patients with moderate or severe problems in at least one dimension of the EQ5D was significantly higher than in the general population (90.1 vs. 35.1%, P < 0.001). The mean EQ-VAS score in PD was lower than in the general population (48.9 ± 19.6 vs. 77.0 ± 20.8, P < 0.001). Social support (number of household members) was identified as an independent social determinant of HrQoL. Demographic and clinical determinants were age, depression, UPDRS and motor fluctuations. The analysis of determinants of HrQoL showed that a greater attention should be paid to social support and home care. Our data on HrQoL in PD should be considered in the development of new health care programs.
KeywordsParkinson’s disease Quality of life EQ-5D Austria
This study was supported by a grant of the European Commission (QLRT-2001-000 20) and the German Ministry of Education and Research (Competence network Parkinson syndromes; Nr.: 01GI9901/1). The authors’ work was independent of the funder.
Conflict of interest statement
All authors declare that they have no conflict of interest.
- 10.Greiner W, Weijnen T, Nieuwenhuizen M, Oppe S, Badia X, Busschbach J, Buxton M, Dolan P, Kind P, Krabbe P, Ohinmaa A, Parkin D, Roset M, Sintonen H, Tsuchiya A, de Charro F (2003) A single European currency for EQ-5D health states. Results from a six-country study. Eur J Health Econ 4:222–231CrossRefPubMedGoogle Scholar
- 11.Harrell FE (2001) Regression modeling strategies. Springer, New YorkGoogle Scholar
- 15.Konig HH, Bernert S, Angermeyer MC, Matschinger H, Martinez M, Vilagut G, Haro JM, de Girolamo G, de Graaf R, Kovess V, Alonso J (2009) Comparison of population health status in six European countries: results of a representative survey using the EQ-5D questionnaire. Med Care 47:255–261CrossRefPubMedGoogle Scholar
- 29.Statistik Austria Statistisches Jahrbuch (2009) http://www.statistik.at/web_de/services/stat_jahrbuch/index.html. Accessed 20 December 2008
- 35.Winter Y, von Campenhausen S, Brozova H, Skoupa J, Reese JP, Botzel K, Eggert K, Oertel WH, Dodel R, Ruzicka E (2009) Costs of illness of Parkinson’s disease in Eastern Europe: a Czech cohort study. Parkinsonism Relat Disord [Epub ahead of print]Google Scholar
- 37.World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. World Health Organization, GenevaGoogle Scholar